{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:49:07Z","timestamp":1792187347577,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) is an increasingly common cause of respiratory illness in adult non\u2010immunocompromised patients. Oral ribavirin was reported to improve outcomes of RSV infection in immunocompromised patients. This study aimed to determine the outcomes of non\u2010immunocompromised patients hospitalized with RSV\u2010associated acute respiratory illnesses (RSV\u2010ARI), the factors independently associated with the outcomes and the effect of oral ribavirin treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, observational cohort study included 175 adults admitted to the hospital with virologically confirmed RSV\u2010ARI during 2014\u20132019. Severe ARI was identified using Infectious Diseases Society of America\/American Thoracic Society (IDSA\/ATS) criteria for severe community\u2010acquired pneumonia. The primary outcome was all\u2010cause mortality within 30\u2009days after enrollment. A multivariable Cox model was performed to identify significant predictors of mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age was 76\u2009\u00b1\u200912.7\u2009years. Seventy\u2010eight (44.6%) patients met the diagnostic criteria for severe ARI. Thirty\u2010six (20.6%) patients required invasive mechanical ventilation, and 11 (6.3%) required vasopressor. Ninety\u2010nine (56.6%) patients received oral ribavirin treatment, and 52 (29.7%) received systemic corticosteroids. Forty\u2010one (23.4%) patients had evidence of bacterial infection. Overall mortality was 7.4%. Mortality among patients with non\u2010severe ARI and severe ARI was 1.04% and 15.4%, respectively. Estimated glomerular filtration rate &lt;50\u2009ml\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      , severe ARI, systemic corticosteroids, and bacterial infection were independently associated with higher risk of mortality. Treatment with oral ribavirin was the only factor associated with reduced mortality (adjusted HR: 0.19, 95% CI: 0.04\u20130.9,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RSV\u2010ARI may result in significant mortality and health care utilization. Treatment with oral ribavirin may improve survival in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.12971","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T04:43:59Z","timestamp":1644641039000},"page":"767-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Respiratory syncytial virus\u2010associated acute respiratory illness in adult non\u2010immunocompromised patients: Outcomes, determinants of outcomes, and the effect of oral ribavirin treatment"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6576-1690","authenticated-orcid":false,"given":"Phunsup","family":"Wongsurakiat","sequence":"first","affiliation":[{"name":"Division of Respiratory Diseases and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwadol","family":"Sunhapanit","sequence":"additional","affiliation":[{"name":"Uttaradit Hospital  Tha It Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisa","family":"Muangman","sequence":"additional","affiliation":[{"name":"Diagnostic Division, Department of Radiology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000232560.22098.4e"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9901004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043951"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182321"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz059"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit471"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy991"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00169714"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt111"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit639"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12510"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12844"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy760"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12194"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400040058013"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(94)70168-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-017-1514-x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-015-0258-9"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002514"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1581ST"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.11.014"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa361"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25568"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12754"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-018-3407-3"},{"issue":"12","key":"e_1_2_11_27_1","article-title":"Respiratory syncytial virus infection: Its propensity for bacterial coinfection and related mortality in elderly adults. 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