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Participants were stratified by self\u2010report of having known contact with a COVID\u201019 case in the 14\u2009days prior to illness onset. Vaccine effectiveness was evaluated using the test\u2010negative study design and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 2229 participants, 283\/451 (63%) of those reporting contact and 331\/1778 (19%) without known contact tested SARS\u2010CoV\u20102\u2010positive. Adjusted vaccine effectiveness was 71% (95% confidence interval [CI], 49%\u201383%) among fully vaccinated participants reporting a known contact versus 80% (95% CI, 72%\u201386%) among those with no known contact (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value for interaction\u2009=\u20090.2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study contributes to growing evidence of the benefits of vaccinations in preventing COVID\u201019 and support vaccination recommendations and the importance of efforts to increase vaccination coverage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.12973","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T20:29:46Z","timestamp":1644956986000},"page":"673-679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Vaccine effectiveness against COVID\u201019 among symptomatic persons aged \u226512\u2009years with reported contact with COVID\u201019 cases, February\u2013September 2021"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5205-966X","authenticated-orcid":false,"given":"Jessie R.","family":"Chung","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward A.","family":"Belongia","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Institute  Marshfield Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huong Q.","family":"McLean","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Institute  Marshfield Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4627-1378","authenticated-orcid":false,"given":"Jennifer P.","family":"King","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Institute  Marshfield Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-2690","authenticated-orcid":false,"given":"Mary Patricia","family":"Nowalk","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Schools of the Health Sciences and University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard K.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Schools of the Health Sciences and University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krissy","family":"Moehling Geffel","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Schools of the Health Sciences and University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily T.","family":"Martin","sequence":"additional","affiliation":[{"name":"School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold S.","family":"Monto","sequence":"additional","affiliation":[{"name":"School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois E.","family":"Lamerato","sequence":"additional","affiliation":[{"name":"Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjusha","family":"Gaglani","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Health  Dallas TX USA"},{"name":"Texas A&amp;M University College of Medicine  Temple Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Health  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Volz","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Health  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Washington Health Research Institute  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan","family":"Flannery","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia 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Available at:https:\/\/www.cdc.gov\/vaccines\/covid\u201019\/clinical\u2010considerations\/covid\u201019\u2010vaccines\u2010us.html?CDC_AA_refVal=https\u20103A\u20102F\u20102Fwww.cdc.gov\u20102Fvaccines\u20102Fcovid\u201019\u20102Finfo\u2010by\u2010product\u20102Fclinical\u2010considerationshtml#dosing\u2010schedule. Accessed November 16 2021."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.02.053"},{"key":"e_1_2_10_8_1","unstructured":"Centers for Disease Control and Prevention.COVID data tracker|variant proportions. Available at:https:\/\/covid.cdc.gov\/covid-data-tracker\/#variant-proportions. 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