{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:54:39Z","timestamp":1785772479522,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Influenza and respiratory syncytial virus (RSV) are associated with substantial morbidity and mortality in the United States. We assessed risk factors for severe disease and medical resource utilization (MRU) among US adults hospitalized with influenza or RSV in the Hospitalized Acute Respiratory Tract Infection (HARTI) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HARTI was a prospective global (40 centers, 12 countries) epidemiological study of adults hospitalized with acute respiratory tract infections conducted across the 2017\u20132019 epidemic seasons. Patients with confirmed influenza or RSV were followed up to 3\u00a0months post\u2010discharge. Baseline characteristics, prevalence of core risk factors (CRFs) for severe disease (age \u226565\u2009years, chronic heart or renal disease, chronic obstructive pulmonary disease, or asthma), and MRU were summarized descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The US cohort included 280 influenza\u2010positive and 120 RSV\u2010positive patients. RSV patients were older (mean: 63.1 vs. 59.7\u00a0years) and a higher proportion had CRFs (87.5% vs. 81.4%). Among those with CRFs (influenza, n\u2009=\u2009153; RSV, n\u2009=\u200999), RSV patients required longer hospitalizations (median length of stay: 4.5\u00a0days) and a greater proportion (79.8%) required oxygen supplementation during hospitalization compared with influenza patients (4.0\u00a0days and 59.5%, respectively). At 3\u00a0months post\u2010discharge, a greater proportion of RSV patients with CRFs reported use of antibiotics, antitussives, bronchodilators, and inhaled and systemic steroids versus those with influenza and CRFs. Many patients with CRFs reported hospital readmission at 3\u00a0months post\u2010discharge (RSV: 13.4%; influenza: 11.9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MRU during and post\u2010hospitalization due to RSV in adults is similar to or greater than that of influenza. Enhanced RSV surveillance and preventive and therapeutic interventions are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.12994","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T21:53:04Z","timestamp":1651009984000},"page":"906-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Risk factors and medical resource utilization in US adults hospitalized with influenza or respiratory syncytial virus in the Hospitalized Acute Respiratory Tract Infection study"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9873-1121","authenticated-orcid":false,"given":"Jessica","family":"Hartnett","sequence":"first","affiliation":[{"name":"Janssen Scientific Affairs, LLC  Titusville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prina","family":"Donga","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs, LLC  Titusville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Ispas","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development  Beerse Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Vandendijck","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development  Beerse Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Anderson","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs, LLC  Titusville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"House","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Suner","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(18)30310\u20104"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.11.04027"},{"key":"e_1_2_8_4_1","unstructured":"World Health Organization.Global influenza strategy.2019.https:\/\/www.who.int\/publications\/i\/item\/9789241515320. Accessed January 3 2022."},{"key":"e_1_2_8_5_1","unstructured":"National Institutes of Health National Institute of Allergy and Infectious Diseases.Respiratory syncytial virus (RSV). 2008.https:\/\/www.niaid.nih.gov\/diseases-conditions\/respiratory-syncytial-virus-rsv. Accessed October 5 2021."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)61728\u20100"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.179"},{"key":"e_1_2_8_8_1","unstructured":"Centers for Disease Control and Prevention.Weekly US Map: Influenza Summary Update. 2022.https:\/\/www.cdc.gov\/flu\/weekly\/usmap.htm. Accessed January 4 2022."},{"key":"e_1_2_8_9_1","unstructured":"Centers for Disease Control and Prevention.The National Respiratory and Enteric Virus Surveillance System (NREVSS). 2021.https:\/\/www.cdc.gov\/surveillance\/nrevss\/rsv\/region.html. Accessed January 4 2022."},{"key":"e_1_2_8_10_1","unstructured":"Centers for Disease Control and Prevention.Influenza (flu): past seasons. 2020.https:\/\/www.cdc.gov\/flu\/about\/burden\/past-seasons.html. Accessed January 4 2022."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000257"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy880"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12723"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12325"},{"key":"e_1_2_8_15_1","unstructured":"Centers for Disease Control and Prevention.Respiratory syncytial virus infection (RSV). Trends and Surveillance. 2020.https:\/\/www.cdc.gov\/rsv\/research\/us-surveillance.html. Accessed October 5 2021."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab491"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010017\u20104177\u2010z"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis309"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.03.046"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.05.057"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12912"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2008.03.014"},{"key":"e_1_2_8_23_1","unstructured":"National Health Service.National Early Warning Score (NEWS).https:\/\/www.england.nhs.uk\/ourwork\/clinical\u2010policy\/sepsis\/nationalearlywarningscore\/. Accessed August 11 2021."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1501"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.12.016"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102017\u2010020269"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12903"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa183"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12842"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.649003"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.92"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01327"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.6.1442"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2110275"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2022.2020248"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.883"},{"key":"e_1_2_8_37_1","unstructured":"Centers for Disease Control and Prevention.Different types of flu vaccines. 2021.https:\/\/www.cdc.gov\/flu\/prevent\/different-flu-vaccines.htm. Accessed January 12 2022."},{"key":"e_1_2_8_38_1","unstructured":"US Food and Drug Administration.Influenza (flu) antiviral drugs and related information. 2020.https:\/\/www.fda.gov\/drugs\/information-drug-class\/influenza-flu-antiviral-drugs-and-related-information. Accessed January 12 2022."},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001187"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa361"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2021.1873073"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1251537"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz676"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2021.1889572"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7029a1"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12994","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/irv.12994","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T01:52:18Z","timestamp":1692841938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.12994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/irv.12994"],"URL":"https:\/\/doi.org\/10.1111\/irv.12994","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.12994\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,26]]},"assertion":[{"value":"2022-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}