{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:12:44Z","timestamp":1791756764222,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["VR2\u2010172712"],"award-info":[{"award-number":["VR2\u2010172712"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Understanding the immune response to natural infection by SARS\u2010CoV\u20102 is key to pandemic management, especially in the current context of emerging variants. Uncertainty remains regarding the efficacy and duration of natural immunity against reinfection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an observational prospective cohort study in Canadian healthcare workers (HCWs) with a history of PCR\u2010confirmed SARS\u2010CoV\u20102 infection to (i) measure the average incidence rate of reinfection and (ii) describe the serological immune response to the primary infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our cohort comprised 569 HCWs; median duration of individual follow\u2010up was 371\u2009days. We detected six cases of reinfection in absence of vaccination between August 21, 2020, and March 1, 2022, for a reinfection incidence rate of 4.0 per 100 person\u2010years. Median duration of seropositivity was 415\u2009days in symptomatics at primary infection compared with 213\u2009days in asymptomatics (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Other characteristics associated with prolonged seropositivity for IgG against the spike protein included age over 55\u2009years, obesity, and non\u2010Caucasian ethnicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among unvaccinated healthcare workers, reinfection with SARS\u2010CoV\u20102 following a primary infection remained rare.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.12997","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T06:20:29Z","timestamp":1651731629000},"page":"916-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The REinfection in COVID\u201019 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workers"],"prefix":"10.1111","volume":"16","author":[{"given":"\u00c9tienne","family":"Racine","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Occupational Health McGill University  Montreal Quebec Canada"},{"name":"Sainte\u2010Justine Hospital Health and Research Center  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-4662","authenticated-orcid":false,"given":"Guy","family":"Boivin","sequence":"additional","affiliation":[{"name":"Department of Microbiology\u2010Immunology and Infectious Diseases Laval University  Quebec City Quebec Canada"},{"name":"Infectious and Immune Diseases Axis Research Center of the Centre Hospitalier de l'Universit\u00e9 Laval  Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Longtin","sequence":"additional","affiliation":[{"name":"Jewish General Hospital and Lady Davis Research 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