{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:15:01Z","timestamp":1790766901340,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","award":["MR\/L015080"],"award-info":[{"award-number":["MR\/L015080"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","award":["MR\/T030062\/1"],"award-info":[{"award-number":["MR\/T030062\/1"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","award":["MR\/V028367\/1"],"award-info":[{"award-number":["MR\/V028367\/1"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Omicron (lineage B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) was first reported in Wales, UK, on 3 December 2021. The aim of the study was to describe the first 1000 cases of the Omicron variant by demographic, vaccination status, travel and severe outcome status and compare this to contemporaneous cases of the Delta variant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Testing, typing and contact tracing data were collected by Public Health Wales and analysis undertaken by the Communicable Disease Surveillance Centre (CDSC). Risk ratios for demographic factors and symptoms were calculated comparing Omicron cases to Delta cases identified over the same time period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>By 14 December 2021, 1000 cases of the Omicron variant had been identified in Wales. Of the first 1000, just 3% of cases had a prior history of travel revealing rapid community transmission. A higher proportion of Omicron cases were identified in individuals aged 20\u201339, and most cases were double vaccinated (65.9%) or boosted (15.7%). Age\u2010adjusted analysis also revealed that Omicron cases were less likely to be hospitalised (0.4%) or report symptoms (60.8%). Specifically a significant reduction was observed in the proportion of Omicron cases reporting anosmia (8.9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Key findings include a lower risk of anosmia and a reduced risk of hospitalisation in the first 1000 Omicron cases compared with co\u2010circulating Delta cases. We also identify that existing measures for travel restrictions to control importations of new variants identified outside the United Kingdom did not prevent the rapid ingress of Omicron within Wales.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13021","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T02:43:35Z","timestamp":1657680215000},"page":"986-993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Epidemiological analysis of the first 1000 cases of SARS\u2010CoV\u20102 lineage BA.1 (B.1.1.529, Omicron) compared with co\u2010circulating Delta in Wales, UK"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5383-6053","authenticated-orcid":false,"given":"Nicole","family":"Pacchiarini","sequence":"first","affiliation":[{"name":"Communicable Disease Surveillance Centre (CDSC) Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2679-7217","authenticated-orcid":false,"given":"Clare","family":"Sawyer","sequence":"additional","affiliation":[{"name":"Communicable Disease Surveillance Centre (CDSC) Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-4987","authenticated-orcid":false,"given":"Christopher","family":"Williams","sequence":"additional","affiliation":[{"name":"Communicable Disease Surveillance Centre (CDSC) Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryn","family":"Sutton","sequence":"additional","affiliation":[{"name":"Communicable Disease Surveillance Centre (CDSC) Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Roberts","sequence":"additional","affiliation":[{"name":"Communicable Disease Surveillance Centre (CDSC) Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicity","family":"Simkin","sequence":"additional","affiliation":[{"name":"Communicable Disease Surveillance Centre (CDSC) Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"King","sequence":"additional","affiliation":[{"name":"Communicable Disease Surveillance Centre (CDSC) Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"McClure","sequence":"additional","affiliation":[{"name":"Communicable Disease Surveillance Centre (CDSC) Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0645-2764","authenticated-orcid":false,"given":"Simon","family":"Cottrell","sequence":"additional","affiliation":[{"name":"Communicable Disease Surveillance Centre (CDSC) Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Clayton","sequence":"additional","affiliation":[{"name":"Informatics Division, Operations and Finance Directorate Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Beazer","sequence":"additional","affiliation":[{"name":"Pathogen Genomics Unit Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3654-3923","authenticated-orcid":false,"given":"Catie","family":"Williams","sequence":"additional","affiliation":[{"name":"Pathogen Genomics Unit Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6196-022X","authenticated-orcid":false,"given":"Sara M.","family":"Rey","sequence":"additional","affiliation":[{"name":"Pathogen Genomics Unit Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2394-6504","authenticated-orcid":false,"given":"Thomas R.","family":"Connor","sequence":"additional","affiliation":[{"name":"Pathogen Genomics Unit Public Health Wales  Cardiff Wales UK"},{"name":"Cardiff University School of Biosciences Cardiff University  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8934-0930","authenticated-orcid":false,"given":"Catherine","family":"Moore","sequence":"additional","affiliation":[{"name":"Wales Specialist Virology Centre, Microbiology Public Health Wales  Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"PeacockT.B.1.1 decendant associated with southern Africa with high number of spike mutations."},{"key":"e_1_2_12_3_1","unstructured":"World Health Organization W.Classification of Omicron (B.1.1.529): SARS\u2010CoV\u20102 variant of concern."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2021.08.014"},{"key":"e_1_2_12_5_1","unstructured":"PatonR OvertonC WardT.Infectious disease modelling team. The spread of Omicron and replacement of Delta in the UK*;2022."},{"key":"e_1_2_12_6_1","unstructured":"UKHSA.Latest REACT\u20101 findings show Omicron infections rising fast while highlighting success of vaccination programmes."},{"key":"e_1_2_12_7_1","unstructured":"Wales PH.Public Health Wales statement on cases of Omicron variant of coronavirus in Wales."},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.es.2021.26.50.2101146"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.es.2022.27.11.2200143"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.12.30.21268565"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.es.2022.27.9.2200121"},{"key":"e_1_2_12_12_1","unstructured":"UKHSA.6 African countries added to red list to protect public health as UK designates new variant under investigation."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2021.26.50.2101147"},{"key":"e_1_2_12_14_1","unstructured":"World Health Organization W.WHO advice for international traffic in relation to the SARS\u2010CoV\u20102 Omicron variant (B.1.1.529)."},{"key":"e_1_2_12_15_1","unstructured":"UKHSA.SARS\u2010CoV\u20102 variants of concern and variants under investigation in England: technical briefing: update on hospitalisation and vaccine effectiveness for Omicron VOC\u201021NOV\u201001 (B.1.1.529). Vol 01;2021."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(22)00017\u20104"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2022.27.4.2200077"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.13021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/irv.13021","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.13021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T12:01:43Z","timestamp":1722427303000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.13021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,12]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/irv.13021"],"URL":"https:\/\/doi.org\/10.1111\/irv.13021","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.13021\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13021\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13021\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13021\/v2\/response1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,12]]},"assertion":[{"value":"2022-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}