{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:46:56Z","timestamp":1772160416495,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infection control during COVID\u201019 outbreaks in nursing facilities is a critical public health issue. Antibody responses before and after the third (booster) dose of SARS\u2010CoV\u20102 vaccination in nursing home residents have not been fully characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 117 individuals: 54 nursing home residents (mean age, 83.8\u00a0years; 39 SARS\u2010CoV\u20102\u2010naive and 15 previously infected) and 63 healthcare workers (mean age, 45.8\u00a0years; 32 SARS\u2010CoV\u20102\u2010naive and 31 previously infected). Anti\u2010spike (receptor\u2010binding domain [RBD]) and anti\u2010nucleocapsid antibody responses to BNT162b2 mRNA vaccination and their related factors were evaluated using pre\u2010 (shortly and 6\u2009months after the second dose) and post\u2010booster vaccination samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median anti\u2010spike (RBD) IgG level in SARS\u2010CoV\u20102\u2010naive residents 6\u2009months after the second dose was the lowest among the four groups, with a decreasing rate of over 90%. The median rate of increase before and after the third dose in SARS\u2010CoV\u20102\u2010naive residents was significantly higher than that in SARS\u2010CoV\u20102\u2010naive healthcare workers (64.1\u2010 vs. 37.0\u2010fold,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003), with the highest level among the groups. The IgG ratio of SARS\u2010CoV\u20102\u2010naive residents to healthcare workers after the second and third doses changed from one\u2010fifth (20%) to one\u2010half (50%). The rate of increase after the third dose in previously infected individuals was three\u2010 to fourfold, regardless of residents or healthcare workers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Advanced aged nursing home residents, poor responders in the initial SARS\u2010CoV\u20102 vaccine series, could obtain sufficient antibody responses with the additional booster dose, despite more than 6\u2009months after the second.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13030","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T02:40:27Z","timestamp":1660358427000},"page":"1066-1071","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pronounced antibody elevation after SARS\u2010CoV\u20102 BNT162b2 mRNA booster vaccination in nursing home residents"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8804-3181","authenticated-orcid":false,"given":"Yong","family":"Chong","sequence":"first","affiliation":[{"name":"Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences (The First Department of Internal Medicine)  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeyuki","family":"Goto","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences (The First Department of Internal Medicine)  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Tani","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences (The First Department of Internal Medicine)  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Yonekawa","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences (The First Department of Internal Medicine)  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Ikematsu","sequence":"additional","affiliation":[{"name":"Japan Physicians Association  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Shimono","sequence":"additional","affiliation":[{"name":"Center for the Study of Global Infection Kyushu University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Medical Corporation SOUSEIKAI, Kanenokuma Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Akashi","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences (The First Department of Internal Medicine)  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.8524"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7034e3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2114228"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2114583"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001540\u20101"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2113468"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.0470"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab963"},{"key":"e_1_2_9_10_1","first-page":"1690","article-title":"Dynamics of the cellular and humoral immune response after BNT162b2 mRNA Covid\u201019 vaccination in Covid\u201019 naive nursing home residents","volume":"224","author":"Praet JTV","year":"2021","journal-title":"J Infect Dis"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","unstructured":"CanadayDH OyebanjiOA WhiteE et al.Significantly elevated antibody levels and neutralization titers in nursing home residents after SARS\u2010CoV\u20102 BNT162b2 mRNA booster vaccination.medRxiv;2021.","DOI":"10.1101\/2021.12.07.21267179"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010021\u201005972\u20105"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2021.10.011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104066"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab584"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119497"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn7591"}],"container-title":["Influenza and Other Respiratory 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