{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:27:02Z","timestamp":1780543622958,"version":"3.54.1"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004343","name":"3M","doi-asserted-by":"publisher","award":["HR0011\u201019\u20103\u20100006"],"award-info":[{"award-number":["HR0011\u201019\u20103\u20100006"]}],"id":[{"id":"10.13039\/100004343","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Seasonal influenza annually causes significant morbidity and mortality, and unpredictable respiratory virus zoonoses, such as the current COVID\u201019 pandemic, can threaten the health and lives of millions more. Molecular iodine (I\n                      <jats:sub>2<\/jats:sub>\n                      ) is a broad\u2010spectrum, pathogen\u2010nonspecific antiseptic agent that has demonstrated antimicrobial activity against a wide range of bacteria, virus, and fungi.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated a commercially available antiseptic, a non\u2010irritating formulation of iodine (5% povidone\u2010iodine) with a film\u2010forming agent that extends the duration of the iodine's antimicrobial activity, for its ability to prevent influenza virus transmission between infected and susceptible animals in the guinea pig model of influenza virus transmission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed that a once\u2010daily topical application of this long\u2010lasting antiseptic to the nares of either the infected virus\u2010donor guinea pig or the susceptible virus\u2010recipient guinea pig, or to the nares of both animals, prior to virus inoculation effectively reduced transmission of a highly transmissible influenza A virus, even when the donor and recipient guinea pigs shared the same cage. Daily treatment of the recipient guinea pig starting 1\u00a0day after initial exposure to an infected donor guinea pig in the same cage was similarly effective in preventing detectable influenza virus infection in the recipient animal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We conclude that a daily application of this antiseptic formulation is efficacious in reducing the transmission of influenza A virus in the guinea pig model, and further study in this and other preclinical models is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13035","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T01:39:46Z","timestamp":1665625186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intranasal antisepsis to reduce influenza virus transmission in an animal model"],"prefix":"10.1111","volume":"17","author":[{"given":"Nassima","family":"Gaaloul ben Hnia","sequence":"first","affiliation":[{"name":"Department of Microbiology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew Kipkemboi","family":"Komen","sequence":"additional","affiliation":[{"name":"Department of Microbiology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie F.","family":"Wlaschin","sequence":"additional","affiliation":[{"name":"Corporate Research Materials Laboratory 3M  St. Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjani V.","family":"Parthasarathy","sequence":"additional","affiliation":[{"name":"Medical Solutions Division 3M  St. Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Landgrebe","sequence":"additional","affiliation":[{"name":"Medical Solutions Division 3M  St. Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-2841","authenticated-orcid":false,"given":"Nicole M.","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Department of Microbiology Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Division of Infectious Diseases, Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.03.046"},{"key":"e_1_2_8_3_1","unstructured":"CDC.Burden of influenza. 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