{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:27:03Z","timestamp":1789550823457,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001857"],"award-info":[{"award-number":["UL1TR001857"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["5U01IP001035\u201002"],"award-info":[{"award-number":["5U01IP001035\u201002"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute respiratory infections (ARIs) result in millions of illnesses and hundreds of thousands of hospitalizations annually in the United States. The responsible viruses include influenza, parainfluenza, human metapneumovirus, coronaviruses, respiratory syncytial virus (RSV), and human rhinoviruses. This study estimated the population\u2010based hospitalization burden of those respiratory viruses (RVs) over 4\u2009years, from July 1, 2015 to June 30, 2019, among adults \u226518\u2009years of age for Allegheny County (Pittsburgh), Pennsylvania.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used population\u2010based statewide hospital discharge data, health system electronic medical record (EMR) data for RV tests, census data, and a published method to calculate burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 26,211 eligible RV tests, 67.6% were negative for any virus. The viruses detected were rhinovirus\/enterovirus (2552; 30.1%), influenza A (2,299; 27.1%), RSV (1082; 12.7%), human metapneumovirus (832; 9.8%), parainfluenza (601; 7.1%), influenza B (565; 6.7%), non\u2010SARS\u2010CoV\u20102 coronavirus (420; 4.9% 1.5\u00a0years of data available), and adenovirus (136; 1.6%). Most tests were among female (58%) and White (71%) patients with 60% of patients \u226565\u2009years, 24% 50\u201364\u2009years, and 16% 18\u201349\u2009years. The annual burden ranged from 137\u2013174\/100,000 population for rhinovirus\/enterovirus; 99\u2013182\/100,000 for influenza A; and 56\u201381\/100,000 for RSV. Among adults &lt;65\u2009years, rhinovirus\/enterovirus hospitalization burden was higher than influenza A; whereas the reverse was true for adults \u226565\u2009years. RV hospitalization burden increased with increasing age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These virus\u2010specific ARI population\u2010based hospital burden estimates showed significant non\u2010influenza burden. These estimates can serve as the basis for several areas of research that are essential for setting funding priorities and guiding public health policy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13040","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T02:25:08Z","timestamp":1661221508000},"page":"1133-1140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Population\u2010based hospitalization burden estimates for respiratory viruses, 2015\u20132019"],"prefix":"10.1111","volume":"16","author":[{"given":"Richard K.","family":"Zimmerman","sequence":"first","affiliation":[{"name":"Department of Family Medicine University of Pittsburgh School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. K.","family":"Balasubramani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh School of Public Health  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E. A.","family":"D'Agostino","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh School of Public Health  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Division of Infectious Diseases\/Pharmacy Department UPMC Health System  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Yassin","sequence":"additional","affiliation":[{"name":"Infection Control Department UPMC Mercy Hospital  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald B.","family":"Middleton","sequence":"additional","affiliation":[{"name":"Department of Medical Education UPMC St. Margaret Hospital  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda P.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases University of Pittsburgh School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole D.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine UPMC Passavant Hospital  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Landis","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine UPMC Passavant Hospital  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine UPMC Shadyside Hospital  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Suyama","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine UPMC Magee\u2010Women's Hospital  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Weissman","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine UPMC Magee\u2010Women's Hospital  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-2690","authenticated-orcid":false,"given":"Mary Patricia","family":"Nowalk","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of Pittsburgh School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"FoundationKF.World Lung Foundation report highlights prevalence of acute respiratory Infections Worldwide 1\/22\/2022.https:\/\/www.kff.org\/news-summary\/world-lung-foundation-report-highlights-prevalence-of-acute-respiratory-infections-worldwide\/"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100986"},{"key":"e_1_2_8_4_1","unstructured":"Updated 10\/25\/2018 Accessed January 19 2022 Prevention CfDCa. Disease burden of flu"},{"key":"e_1_2_8_5_1","unstructured":"Prevention CfDCa. Respiratory syncytial virus infection (RSV). Updated 12\/18\/2020. 12\/10\/2021.https:\/\/www.cdc.gov\/rsv\/research\/us-surveillance.html"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy662"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702090"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.360.6389.673\u2010c"},{"issue":"1","key":"e_1_2_8_9_1","first-page":"43","article-title":"Epidemiologic analysis of respiratory viral infections mainly in hospitalized children and adults in a Midwest University medical center after the implementation of a 14\u2010virus multiplex nucleic acid amplification test","volume":"147","author":"Arbefeville S","year":"2017","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12145"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12247"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010015\u20100806\u20102"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268813002471"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240309"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1958610"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01384\u201012"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104261"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(19)30264\u20105"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00249\u201018"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12629"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/274679"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","unstructured":"ZimmermanRK RinaldoCR NowalkMP et al. 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