{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:46:58Z","timestamp":1772160418764,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20JC141020002"],"award-info":[{"award-number":["20JC141020002"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to understand the epidemiological and clinical characteristics of pediatric SARS\u2010CoV\u20102 infection during the early stage of Omicron variant outbreak in Shanghai.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included local COVID\u201019 cases &lt;18\u2009years in Shanghai referred to the exclusively designated hospital from March 7 to March 31, 2022. Clinical data, epidemiological exposure, and COVID\u201019 vaccination status were collected. Relative risks (RRs) were calculated to assess the effect of vaccination on symptomatic infection and febrile disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 376 pediatric cases of COVID\u201019 (median age: 6.0\u2009\u00b1\u20094.2\u2009years) were referred to the designated hospital, including 257 (68.4%) symptomatic cases and 119 (31.6%) asymptomatic cases. Of the 307 (81.6%) children \u22653\u2009years eligible for COVID\u201019 vaccination, 110 (35.8%) received two doses of vaccines. The median interval between the completion of two\u2010dose vaccination and infection was 3.5 (interquartile range [IQR]: 3, 4.5) months. Compared with no vaccination, two\u2010dose COVID\u201019 vaccination reduced the risks of symptomatic infection and febrile disease by 35% (RR 0.65, 95% confidence interval [CI]: 0.53\u20130.79) and 33% (RR 0.64, 95% CI: 0.51\u20130.81) among confirmed cases. Eighty\u2010four percent of symptomatic cases had fever (mean duration: 1.7\u2009\u00b1\u20091.0.8\u2009days), 40.5% had cough, and 16.4% had transient leukopenia. Three hundred and seven (81.6%) had an epidemiological exposure in household (69.1%), school (21.8%), and residential area (8.8%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The surge of pediatric COVID\u201019 cases and multiple transmission model reflect wide dissemination of Omicron variant in the community. Asymptomatic infection is common among Omicron\u2010infected children. COVID\u201019 vaccination can offer some protection against symptomatic infection and febrile disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13044","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T05:41:52Z","timestamp":1661924512000},"page":"1059-1065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Epidemiological and clinical features of SARS\u2010CoV\u20102 infection in children during the outbreak of Omicron variant in Shanghai, March 7\u201331, 2022"],"prefix":"10.1111","volume":"16","author":[{"given":"Xiangshi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailing","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongqiu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixue","family":"Wang","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimei","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gongbao","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Medical Administration Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiehao","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qirong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3491-5298","authenticated-orcid":false,"given":"Mei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization.COVID\u201019 disease in children and adolescents: scientific brief 29 September 2021.2021.https:\/\/www.who.int\/publications\/i\/item\/WHO-2019-nCoV-Sci_Brief-Children_and_adolescents-2021.1"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization.Pulse survey on continuity of essential health services during the COVID\u201019 pandemic: 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