{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:32:21Z","timestamp":1785148341383,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anaphylaxis following influenza vaccination is a rare but serious problem. The underlying immune responses are not well understood. This study elucidated the IgE and IgG antibody responses in healthy children and adolescents following inactivated influenza vaccines (IIVs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The efficacy and safety of quadrivalent IIV (QIV) and trivalent IIV (TIV) were compared in healthy subjects aged 0\u201318\u2009years. Serum IIV\u2010specific IgE, IgG, and IgG4 levels (sIgE, sIgG, and sIgG4) were measured with ImmunoCAP. Hemagglutination inhibition (HI) assay was performed for each influenza virus subtype. Sera from earlier patients who developed anaphylaxis to different IIVs were similarly tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 393 subjects were enrolled: 96 were 6\u00a0months\u22122\u00a0years old, 100 were 3\u20135\u00a0years old, 100 were 6\u201312\u2009years old, and 97 were 13\u201318\u2009years old. No anaphylaxis was observed. Generally, QIV and TIV induced similar antibody responses. IIV\u2010sIgE levels rose significantly after vaccination in the 6\u00a0months\u20132\u2009years old and 3\u20135\u2009years old groups, did not change in the 6\u201312\u2009years old group, and decreased in the 13\u201318\u2009years old group. In contrast, the IIV\u2010sIgG4\/sIgE ratio increased significantly after vaccination in all age groups. Sensitized subjects had significantly higher HI titers and IIV\u2010sIgG levels in the youngest age group and higher IIV\u2010sIgG4 levels in all age groups compared with the non\u2010sensitized. The IIV\u2010sIgG4\/sIgE ratio in five patients with anaphylaxis was significantly lower than in age\u2010matched healthy subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IIVs induce IgE sensitization in healthy children but also robust IgG4 responses that may protect them from anaphylaxis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13053","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T01:28:28Z","timestamp":1662773308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High prevalence of IgE sensitization to inactivated influenza vaccines, yet robust IgG4 responses, in a healthy pediatric population"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8328-9062","authenticated-orcid":false,"given":"Prince Baffour","family":"Tonto","sequence":"first","affiliation":[{"name":"Allergy Center and Infectious Disease Center National Hospital Organization Mie National Hospital  Tsu Japan"},{"name":"Department of Child Health and Development Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuho","family":"Nagao","sequence":"additional","affiliation":[{"name":"Allergy Center and Infectious Disease Center National Hospital Organization Mie National Hospital  Tsu Japan"},{"name":"Department of Child Health and Development Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Suga","sequence":"additional","affiliation":[{"name":"Allergy Center and Infectious Disease Center National Hospital Organization Mie National Hospital  Tsu Japan"},{"name":"Department of Child Health and Development Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyosu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Allergy Center and Infectious Disease Center National Hospital Organization Mie National Hospital  Tsu Japan"},{"name":"Department of Child Health and Development Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Omura Satoshi Memorial Institute Kitasato University Graduate School of Infection Control Sciences  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Kumagai Pediatric Clinic  Hokuto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9196-9436","authenticated-orcid":false,"given":"Takao","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Allergy Center and Infectious Disease Center National Hospital Organization Mie National Hospital  Tsu Japan"},{"name":"Department of Child Health and Development Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Influenza Vaccine Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.07.048"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40521\u2010019\u201000215\u20100"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.10.020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.08.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.05.106"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.019"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S34152"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2020.12.2.359"},{"key":"e_1_2_10_10_1","unstructured":"Prevention CfDCa.Antigenic characterization content.2019[cited January 12 2022]; Available from:https:\/\/www.cdc.gov\/flu\/about\/professionals\/antigenic.htm#"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.11.071"},{"key":"e_1_2_10_12_1","unstructured":"Products ECfPM.Note for guidance on harmmonisation of requirements for influenza vaccines(CPMP\/BWP\/214\/96). [cited January 14 2022]; Available from:https:\/\/www.ema.europa.eu\/en\/documents\/scientific\u2010guideline\/note\u2010guidance\u2010harmonisation\u2010requirements\u2010influenza\u2010vaccines_en.pdf"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.12.010"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.025"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12953"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081\u20101206(10)61262\u20108"},{"issue":"8","key":"e_1_2_10_17_1","first-page":"1","article-title":"Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization ractices (ACIP), 2009","volume":"58","author":"Fiore AE","year":"2009","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7005a1"},{"issue":"5","key":"e_1_2_10_19_1","first-page":"583","article-title":"Antibody response to influenza vaccination in patients suffering from asthma","volume":"58","author":"Romanowska M","year":"2007","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1144603"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.04.006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20100641"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21145017"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.01.012"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3730"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.7.3478"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161\u20105890(01)00121\u20103"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.3.747"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.4718"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080193"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.014"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2018.1498435"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2014.0010"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000237376"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0264\u2010410X(94)00017\u2010H"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.13053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/irv.13053","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.13053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T17:22:49Z","timestamp":1692465769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.13053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,9]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/irv.13053"],"URL":"https:\/\/doi.org\/10.1111\/irv.13053","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.13053\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13053\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13053\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13053\/v1\/review1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,9]]},"assertion":[{"value":"2022-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13053"}}