{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:38:11Z","timestamp":1789155491843,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Implementation of respiratory virus prevention measures requires detailed understanding of regional epidemiology; however, data from many tropical countries are sparse. We describe etiologies of ambulatory pediatric acute respiratory tract infections (ARTI) in Ecuador immediately preceding the onset of the SARS\u2010CoV\u20102 pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children\u2009&lt;\u20095\u2009years presenting to a designated study site with an ARTI were eligible. Informed consent was obtained. Demographic and clinical data were recorded. A nasopharyngeal swab was collected, processed, and analyzed using multiplex polymerase chain reaction (PCR) for common respiratory pathogens. Rhinovirus\/enterovirus positive samples were further characterized by genomic sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 820 subjects were enrolled in the study between July 2018 and March 2020. A total of 655 (80%) samples identified at least one pathogen. Rhinoviruses (44%) were most common, followed by enteroviruses (17%), parainfluenza viruses (17%), respiratory syncytial virus (RSV) (15%), and influenza viruses (13%). Enterovirus D68 was the most common enterovirus detected and was among the leading causes of bronchiolitis. Seasonal RSV and influenza virus activity were different along the coast compared with the highlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ongoing regional surveillance studies are necessary to optimize available and emerging pathogen\u2010specific preventative measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13056","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T05:09:16Z","timestamp":1664428156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Etiologies of outpatient medically attended acute respiratory infections among young Ecuadorian children prior to the start of the 2020\n                    <scp>SARS\u2010CoV\u20102<\/scp>\n                    pandemic"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4903-2241","authenticated-orcid":false,"given":"Manika","family":"Suryadevara","sequence":"first","affiliation":[{"name":"Department of Pediatrics SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy Pizarro","family":"Fajardo","sequence":"additional","affiliation":[{"name":"Research Center at Hospital Te\u00f3filo D\u00e1vila SUNY Upstate Medical University  Machala Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthya Cueva","family":"Aponte","sequence":"additional","affiliation":[{"name":"Research Center at Hospital Te\u00f3filo D\u00e1vila SUNY Upstate Medical University  Machala Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Luis","family":"Carrillo Aponte","sequence":"additional","affiliation":[{"name":"Research Center at Hospital Te\u00f3filo D\u00e1vila SUNY Upstate Medical University  Machala Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban Ortiz","family":"Prado","sequence":"additional","affiliation":[{"name":"One Health Global Research Group Universidad de las Americas  Quito Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Centro Medico Hidalgo Jaramillo  Quito Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A.","family":"Bonville","sequence":"additional","affiliation":[{"name":"Department of Pediatrics SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Torres","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Octaedro  Quito Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Domachowske","sequence":"additional","affiliation":[{"name":"Department of Pediatrics SUNY Upstate Medical University  Syracuse New York 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