{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T05:25:24Z","timestamp":1785561924198,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Influenza\u2010associated pulmonary aspergillosis (IAPA) is an important complication of severe influenza with high morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective multicenter study in tertiary hospitals in Switzerland during 2017\/2018 and 2019\/2020 influenza seasons. All adults with PCR\u2010confirmed influenza infection and treatment on intensive\u2010care unit (ICU) for &gt;24\u2009h were included. IAPA was diagnosed according to previously published clinical, radiological, and microbiological criteria. We assessed risk factors for IAPA and predictors for poor outcome, which was a composite of in\u2010hospital mortality, ICU length of stay \u22657\u2009days, mechanical ventilation \u22657\u2009days, or extracorporeal membrane oxygenation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred fifty\u2010eight patients (median age 64\u2009years, 45% females) with influenza were included, of which 17 (10.8%) had IAPA. Asthma was more common in IAPA patients (17% vs. 4% in non\u2010IAPA, P\u2009=\u20090.05). Asthma (OR 12.0 [95% CI 2.1\u201367.2]) and days of mechanical ventilation (OR 1.1 [1.1\u20131.2]) were associated with IAPA. IAPA patients frequently required organ supportive therapies including mechanical ventilation (88% in IAPA vs. 53% in non\u2010IAPA, P\u2009=\u20090.001) and vasoactive support (75% vs. 45%, P\u2009=\u20090.03) and had more complications including ARDS (53% vs. 26%, P\u2009=\u20090.04), respiratory bacterial infections (65% vs. 37%, P\u2009=\u20090.04), and higher ICU\u2010mortality (35% vs. 16.4%, P\u2009=\u20090.05). IAPA (OR 28.8 [3.3\u2013253.4]), influenza A (OR 3.3 [1.4\u20137.8]), and higher SAPS II score (OR 1.07 [1.05\u20131.10]) were independent predictors of poor outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>High clinical suspicion, early diagnostics, and therapy are indicated in IAPA because of high morbidity and mortality. Asthma is likely an underappreciated risk factor for IAPA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13059","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T01:39:20Z","timestamp":1668649160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Higher risk for influenza\u2010associated pulmonary aspergillosis (IAPA) in asthmatic patients: A Swiss multicenter cohort study on IAPA in critically ill influenza patients"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1692-5521","authenticated-orcid":false,"given":"Frederike","family":"Waldeck","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Microbiology University Hospital Schleswig Holstein, Campus L\u00fcbeck  L\u00fcbeck 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