{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:01:17Z","timestamp":1781478077626,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infection (ALRI) in young children and is of considerable burden on healthcare systems. Our study aimed to evaluate ALRI hospitalizations related to RSV in children in Portugal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed hospitalizations potentially related to RSV in children aged &lt;5\u00a0years from 2015 to 2018, using anonymized administrative data covering all public hospital discharges in mainland Portugal. Three case definitions were considered: (a) RSV\u2010specific, (b) (a) plus unspecified acute bronchiolitis (RSV\u2010specific &amp; Bronchiolitis), and (c) (b) plus unspecified ALRI (RSV\u2010specific &amp; ALRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 9697 RSV\u2010specific hospitalizations were identified from 2015 to 2018\u2014increasing to 26\u2009062 for RSV\u2010specific &amp; ALRI hospitalizations\u2014of which 74.7% were during seasons 2015\/2016\u20132017\/2018 (November\u2013March). Mean hospitalization rates per season were, for RSV\u2010specific, RSV\u2010specific &amp; Bronchiolitis, and RSV\u2010specific &amp; ALRI, respectively, 5.6, 9.4, and 11.8 per 1000 children aged &lt;5\u00a0years and 13.4, 22.5, and 25.9 in children aged &lt;2\u00a0years. Most RSV\u2010specific hospitalizations occurred in healthy children (94.9%) and in children aged &lt;2\u00a0years (96.3%). Annual direct costs of \u20ac2.4 million were estimated for RSV\u2010specific hospitalizations\u2014rising to \u20ac5.1 million for RSV\u2010specific &amp; ALRI\u2014mostly driven by healthy children (87.6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RSV is accountable for a substantial number of hospitalizations in children, especially during their first year of life. Hospitalizations are mainly driven by healthy children. The variability of the potential RSV burden across case definitions highlights the need for a universal RSV surveillance system to guide prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13066","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T02:40:59Z","timestamp":1668480059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015\u20132018"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6214-3117","authenticated-orcid":false,"given":"Teresa","family":"Bandeira","sequence":"first","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio Lisboa Norte, Faculdade de Medicina Universidade de Lisboa, CAML  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafalda","family":"Carmo","sequence":"additional","affiliation":[{"name":"IQVIA  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Lopes","sequence":"additional","affiliation":[{"name":"IQVIA  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Gomes","sequence":"additional","affiliation":[{"name":"Sanofi  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Martins","sequence":"additional","affiliation":[{"name":"Sanofi  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Guzman","sequence":"additional","affiliation":[{"name":"Sanofi  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Bangert","sequence":"additional","affiliation":[{"name":"Sanofi  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Hospital Pedi\u00e1trico Centro Hospitalar e Universit\u00e1rio de Coimbra  Coimbra Portugal"},{"name":"Faculdade de Medicina Universidade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Janu\u00e1rio","sequence":"additional","affiliation":[{"name":"Hospital Pedi\u00e1trico Centro Hospitalar e Universit\u00e1rio de Coimbra  Coimbra Portugal"},{"name":"Faculdade de Medicina Universidade de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Tom\u00e9","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio Lisboa Central  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Universidade do Porto, Centro Hospitalar Universit\u00e1rio S. 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