{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:44:28Z","timestamp":1791776668080,"version":"4.3.4"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Respiratory syncytial virus (RSV) is responsible for over 30 million lower respiratory tract infections (LRTIs) and 3 million hospitalizations worldwide each year. Despite the risk RSV poses to young children, older adults, and individuals with comorbidities or suppressed immunity, there is limited understanding of RSV symptom presentation across these at\u2010risk groups, and there is no vaccine for RSV. We conducted two systematic literature reviews (SLRs) of studies that document signs and symptoms (S&amp;S) of RSV in (1) children aged \u22645\u00a0years and (2) immunocompromised adolescents and adults, and adults at high risk for severe RSV due to age or comorbidities. Symptom duration and hospital length of stay (LOS) were explored. Electronic database searches were performed following PRISMA guidelines. Studies captured RSV S&amp;S across community and hospital settings. Clinicians and caregivers reported (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200925 studies) nasal discharge\/congestion, cough, shortness of breath, feeding abnormalities, and fever in \u226540% of children across studies and settings. Median hospital stays for children ranged from 2\u00a0days in the United States to 7.5\u00a0days in China. High\u2010risk adults with RSV (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096 studies) commonly (\u226540% of adults) reported cough, sputum, dyspnea, and fever\/feverishness. Median length of hospital stay in adults ranged from 6 to 15\u2009days across studies. Caregivers and clinicians reported similar RSV S&amp;S in young children, including upper and lower respiratory and systemic symptoms. In high\u2010risk and immunocompromised adults, the most frequent (in multiple publications) and commonly reported RSV S&amp;S were primarily LRTI symptoms. RSV symptoms could last for weeks and are variable based on geography.\n                  <\/jats:p>","DOI":"10.1111\/irv.13100","type":"journal-article","created":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T22:15:13Z","timestamp":1675635313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Systematic literature review of the signs and symptoms of respiratory syncytial virus"],"prefix":"10.1111","volume":"17","author":[{"given":"Ann","family":"Colosia","sequence":"first","affiliation":[{"name":"RTI Health Solutions  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Costello","sequence":"additional","affiliation":[{"name":"RTI Health Solutions  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"McQuarrie","sequence":"additional","affiliation":[{"name":"Janssen Global Services  Horsham Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Kato","sequence":"additional","affiliation":[{"name":"Janssen Global Services  Raritan New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Bertzos","sequence":"additional","affiliation":[{"name":"Janssen Global Services  Horsham Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)30938\u20108"},{"key":"e_1_2_10_3_1","unstructured":"KyriakidesS KlugeHHP AmmonA.Joint statement \u2010 Influenza season epidemic kicks off early in Europe as concerns over RSV rise and COVID\u201019 is still a threat. 15Dec22.https:\/\/www.who.int\/europe\/news\/item\/01-12-2022-joint-statement---influenza-season-epidemic-kicks-off-early-in-europe-as-concerns-over-rsv-rise-and-covid-19-is-still-a-threat"},{"key":"e_1_2_10_4_1","unstructured":"Centers for Disease Control and Prevention.Respiratory Syncytial Virus Infection (RSV). 15Dec22.https:\/\/www.cdc.gov\/rsv\/index.html"},{"key":"e_1_2_10_5_1","unstructured":"National Foundation of Infectious Diseases.Respiratory syncytial virus in older adults: a hidden annual epidemic. 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