{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:53:00Z","timestamp":1787014380599,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","award":["RSV00033"],"award-info":[{"award-number":["RSV00033"]}],"id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Globally, the epidemiology of non\u2010SARS\u2010CoV\u20102 respiratory viruses like respiratory syncytial virus (RSV) and influenza virus was remarkably influenced by the implementation of non\u2010pharmacological interventions (NPIs) during the COVID\u201019 pandemic. Our study explored the epidemiological and clinical characteristics of pediatric patients hospitalized with RSV or influenza infection before and during the pandemic after relaxation of NPIs in central China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This hospital\u2010based prospective case\u2010series study screened pediatric inpatients (age\u2009\u2264\u200914\u2009years) enrolled with acute respiratory infections (ARI) for RSV or influenza infection from 2018 to 2021. The changes in positivity rates of viral detection, epidemiological, and clinical characteristics were analyzed and compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median ages of all eligible ARI patients from 2018\u20132019 were younger than those from 2020\u20132021, so were ages of cases infected with RSV or influenza (RSV: 4.2\u2009months vs. 7.2\u2009months; influenza: 27.3\u00a0months vs. 37.0\u2009months). Where the positivity rate for influenza was considerably decreased in 2020\u20132021 (1.4%, 27\/1964) as compared with 2018\u20132019 (2.9%, 94\/3275, P\u2009&lt;\u20090.05), it was increased for RSV (11.4% [372\/3275] vs. 13.3% [262\/1964], P\u2009&lt;\u20090.05) in the same period. The number of severe cases for both RSV and influenza infection were also decreased in 2020\u20132021 compared with 2018\u20132019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The implemented NPIs have had varied impacts on common respiratory viruses. A more effective prevention strategy for RSV infections in childhood is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13103","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T01:49:39Z","timestamp":1675388979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Epidemiological and clinical characteristics of respiratory syncytial virus and influenza infections in hospitalized children before and during the COVID\u201019 pandemic in Central China"],"prefix":"10.1111","volume":"17","author":[{"given":"Lingshuang","family":"Ren","sequence":"first","affiliation":[{"name":"School of Public Health Fudan University, Key Laboratory of Public Health Safety, Ministry of Education  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Children's Hospital Affiliated to Zhengzhou University Henan Children's Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhengzhou Central Hospital Affiliated to Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianli","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Infectious Disease and Biosecurity Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Children's Hospital Affiliated to Zhengzhou University Henan Children's Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhengzhou Central Hospital Affiliated to Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Fang","sequence":"additional","affiliation":[{"name":"Children's Hospital Affiliated to Zhengzhou University Henan Children's Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linsen","family":"Xie","sequence":"additional","affiliation":[{"name":"Zhengzhou Central Hospital Affiliated to Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Children's Hospital Affiliated to Zhengzhou University Henan Children's Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5028-2227","authenticated-orcid":false,"given":"Juan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University, Key Laboratory of Public Health Safety, Ministry of Education  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University, Key Laboratory of Public Health Safety, Ministry of Education  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Jiangxi Province Center for Disease Control and Prevention  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkai","family":"Lian","sequence":"additional","affiliation":[{"name":"Zhengzhou Central Hospital Affiliated to Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangtao","family":"Wang","sequence":"additional","affiliation":[{"name":"Children's Hospital Affiliated to Zhengzhou University Henan Children's Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6335-5648","authenticated-orcid":false,"given":"Hongjie","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University, Key Laboratory of Public Health Safety, Ministry of Education  Shanghai China"},{"name":"Shanghai Institute of Infectious Disease and Biosecurity Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab942"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30721-4"},{"key":"e_1_2_12_4_1","unstructured":"World Health Organization.Influenza update N\u00b0 379.2020Oct 26.https:\/\/www.who.int\/publications\/m\/item\/influenza-update-n-379. 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