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Among 518 participants, hybrid immunity was associated with symptom reduction for dizziness, muscle or limb pain and headache as compared to vaccination only. Moreover, the frequencies of dizziness, cough and muscle or limb pain were lower in participants who had received a booster vaccine dose. Thus, hybrid immunity appeared to be superior in preventing specific symptoms during breakthrough infection compared to vaccination alone. A booster vaccine dose conferred additional symptom reduction.<\/jats:p>","DOI":"10.1111\/irv.13167","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T01:42:35Z","timestamp":1687225355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical symptoms of SARS\u2010CoV\u20102 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination\u2014A prospective multicentre cohort of health professionals (SURPRISE study)"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-8934","authenticated-orcid":false,"given":"Philipp","family":"Kohler","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology Cantonal Hospital St Gallen  St Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baharak","family":"Babouee Flury","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology Cantonal Hospital St Gallen  St Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"G\u00fcsewell","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology Cantonal Hospital St Gallen  St Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Egger","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology Cantonal Hospital St Gallen  St Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onicio","family":"Leal","sequence":"additional","affiliation":[{"name":"Epitrack  Recife Brazil"},{"name":"Department of Economics University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Brucher","sequence":"additional","affiliation":[{"name":"Psychiatry Services of the Canton of St. Gallen (South)  Pf\u00e4fers Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Lemmenmeier","sequence":"additional","affiliation":[{"name":"Clienia Littenheid AG, Private Clinic for Psychiatry and Psychotherapy  Littenheid Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorette","family":"Meier Kleeb","sequence":"additional","affiliation":[{"name":"Division of Occupational Health Kantonsspital Baden  Baden Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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