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post\u2010traumatic stress disorder (PTSD) symptoms, and depression symptoms at 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multi\u2010center prospective cohort study in adult hospitalized patients with acute COVID\u201019. The following in\u2010hospital factors were assessed: delirium; frequency of in\u2010person and virtual visits by friends and family; and hydroxychloroquine, corticosteroid, and remdesivir administration. Twelve\u2010month global cognition was characterized by the MOCA\u2010Blind. Twelve\u2010month PTSD and depression were characterized using the PTSD Checklist for the DSM\u2010V and Hospital Anxiety Depression Scale, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Two hundred three patients completed the 12\u2010month follow\u2010up assessments. Remdesivir use was associated with significantly higher cognition at 12\u2009months based on the MOCA\u2010Blind (adjusted odds ratio [aOR]\u2009=\u20091.98, 95% CI: 1.06, 3.70). Delirium was associated with worsening 12\u2010month PTSD (aOR\u2009=\u20093.44, 95% CI: 1.89, 6.28) and depression (aOR\u2009=\u20092.18, 95% CI: 1.23, 3.84) symptoms. Multiple virtual visits per day during hospitalization was associated with lower 12\u2010month depression symptoms compared to those with less than daily virtual visits (aOR\u2009=\u20090.40, 95% CI: 0.19, 0.85).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Potentially modifiable factors associated with better long\u2010term outcomes included remdesivir use (associated with better cognitive function), avoidance of delirium (associated with less PTSD and depression symptoms), and increased virtual interactions with friends and family (associated with less depression symptoms).<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.13197","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T01:34:55Z","timestamp":1695778495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modifiable in\u2010hospital factors for 12\u2010month global cognition, post\u2010traumatic stress disorder symptoms, and depression symptoms in adults hospitalized with COVID\u201019"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-210X","authenticated-orcid":false,"given":"Jin H.","family":"Han","sequence":"first","affiliation":[{"name":"Critical Illness, Brain Dysfunction, and Survivorship Center Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Geriatric Research, Education, and Clinical Center (GRECC) Tennessee Valley Healthcare System  Nashville Tennessee USA"},{"name":"Department of Emergency Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Critical Illness, Brain Dysfunction, and Survivorship Center Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Geriatric Research, Education, and Clinical Center (GRECC) Tennessee Valley Healthcare System  Nashville Tennessee USA"},{"name":"Division of Allergy, Pulmonary, and Critical Care, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur M.","family":"Orun","sequence":"additional","affiliation":[{"name":"Critical Illness, Brain Dysfunction, and Survivorship Center Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Pulmonary\/Critical Care Medicine, Department of Medicine Intermountain Medical Center and the University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Casey","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Clark","sequence":"additional","affiliation":[{"name":"Division of Geriatrics and Gerontology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"},{"name":"Geriatric Research, Education, and Clinical Center (GRECC) William S Middleton Memorial Veterans Hospital  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Collins","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center (GRECC) Tennessee Valley Healthcare System  Nashville Tennessee USA"},{"name":"Department of Emergency Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemberlyne","family":"Cordero","sequence":"additional","affiliation":[{"name":"Critical Illness, Brain Dysfunction, and Survivorship Center Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adit A.","family":"Ginde","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle N.","family":"Gong","sequence":"additional","affiliation":[{"name":"Division of Critical Care, Division of Pulmonary Medicine, Department of Medicine Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine L.","family":"Hough","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine Oregon Health &amp; 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