{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:26:39Z","timestamp":1778034399415,"version":"3.51.4"},"reference-count":68,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018214","name":"Belgische Federale Overheidsdiensten","doi-asserted-by":"publisher","award":["SEQ\u2010COVID19\u2010LABSURV"],"award-info":[{"award-number":["SEQ\u2010COVID19\u2010LABSURV"]}],"id":[{"id":"10.13039\/100018214","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To support the COVID\u201019 pandemic response, many countries, including Belgium, implemented baseline genomic surveillance (BGS) programs aiming to early detect and characterize new SARS\u2010CoV\u20102 variants. In parallel, Belgium maintained a sentinel network of six hospitals that samples patients with severe acute respiratory infections (SARI) and integrated SARS\u2010CoV\u20102 detection within a broader range of respiratory pathogens. We evaluate the ability of the SARI surveillance to monitor general trends and early signals of viral genetic evolution of SARS\u2010CoV\u20102 and compare it with the BGS as a reference model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine\u2010hundred twenty\u2010five SARS\u2010CoV\u20102 positive samples from patients fulfilling the Belgian SARI definition between January 2020 and December 2022 were sequenced using the ARTIC Network amplicon tiling approach on a MinION platform. Weekly variant of concern (VOC) proportions and types were compared to those that were circulating between 2021 and 2022, using 96,251 sequences of the BGS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SARI surveillance allowed timely detection of the Omicron (BA.1, BA.2, BA.4, and BA.5) and Delta (B.1.617.2) VOCs, with no to 2\u00a0weeks delay according to the start of their epidemic growth in the Belgian population. First detection of VOCs B.1.351 and P.1 took longer, but these remained minor in Belgium. Omicron BA.3 was never detected in SARI surveillance. Timeliness could not be evaluated for B.1.1.7, being already major at the start of the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Genomic surveillance of SARS\u2010CoV\u20102 using SARI sentinel surveillance has proven to accurately reflect VOCs detected in the population and provides a cost\u2010effective solution for long\u2010term genomic monitoring of circulating respiratory viruses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13202","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:12:36Z","timestamp":1697173956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genomic monitoring of SARS\u2010CoV\u20102 variants using sentinel SARI hospital surveillance"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0489-3515","authenticated-orcid":false,"given":"Sarah","family":"Denayer","sequence":"first","affiliation":[{"name":"Viral Diseases, National Influenza Centre, Scientific Directorate of Infectious Diseases in Humans Sciensano  Ukkel Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois E.","family":"Dufrasne","sequence":"additional","affiliation":[{"name":"Viral Diseases, National Influenza Centre, Scientific Directorate of Infectious Diseases in Humans Sciensano  Ukkel Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"Monsieurs","sequence":"additional","affiliation":[{"name":"Viral Diseases, National Influenza Centre, Scientific Directorate of Infectious Diseases in Humans Sciensano  Ukkel Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinout","family":"van Eycken","sequence":"additional","affiliation":[{"name":"Viral Diseases, National Influenza Centre, Scientific Directorate of Infectious Diseases in Humans Sciensano  Ukkel Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Houben","sequence":"additional","affiliation":[{"name":"Observational Clinical Trials, Scientific Directorate of infectious Diseases in Humans Sciensano  Ukkel Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Seyler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectiology, Universitair Ziekenhuis Brussel (UZB) Vrije Universiteit Brussel (VUB)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Demuyser","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control, Universitair Ziekenhuis Brussel (UZB) Vrije Universiteit Brussel (VUB)  Brussels Belgium"},{"name":"AIMS Lab, Center for Neurosciences, Faculty of Medicine and Pharmacy Vrije Universiteit Brussel (VUB)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els","family":"van Nedervelde","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectiology, Universitair Ziekenhuis Brussel (UZB) Vrije Universiteit Brussel (VUB)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"CHU UCL Namur, site Mont\u2010Godinne  Yvoir Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9n\u00e9dicte","family":"Delaere","sequence":"additional","affiliation":[{"name":"CHU UCL Namur, site Mont\u2010Godinne  Yvoir Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Magerman","sequence":"additional","affiliation":[{"name":"Infection Control and Clinical 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