{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:39:38Z","timestamp":1766428778211,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Strengthening surveillance systems is a key aspect of outbreak response and was particularly important during the COVID\u201019 pandemic. Respiratory pathogens spread rapidly, and laboratory capacity is key to monitoring the spread. Prior to the pandemic, Iran had established a rapid response team and laboratory network to provide identification, monitoring, and detection of emerging infectious diseases, but did not have the laboratory capacity to respond to COVID\u201019. Following the announcement of the COVID\u201019 pandemic, the rapid response team diverted all attention to supporting COVID\u201019 surveillance. Iran built on the existing national laboratory infrastructure to incorporate SARS\u2010CoV\u20102 surveillance into the response network. Based on existing international protocols, in\u2010house molecular diagnosis capacity was operationalized, and commercial controls and assays were acquired and validated to national standards. The first COVID\u201019 laboratory was operational by January 25, less than 4\u2009weeks before the initial detection of SARS\u2010CoV\u20102 was announced. Assays and support were expanded and rolled out to form the COVID\u201019 National Laboratory Network, which consists of 560 multi\u2010sectoral laboratories covering all provinces of Iran. The national laboratory network supports a wide range of operational capacities, including assay validation and protocol development, quality assurance, respiratory pathogen diagnosis and surveillance, and variant identification and assessment using multiple sequencing platforms. This network has supported the testing of over 55 million samples over the past 36\u2009months using RT\u2010qPCR and has sequenced approximately 2200 samples across the country, contributing the data to international databases, including GISAID.<\/jats:p>","DOI":"10.1111\/irv.13232","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T03:09:33Z","timestamp":1702264173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of Laboratory in Emerging Infectious Disease Control in Iran, Pasteur Institute of Iran, and national laboratory network"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6044-3052","authenticated-orcid":false,"given":"Ali","family":"Maleki","sequence":"first","affiliation":[{"name":"COVID\u201019 National Reference Laboratory Pasteur Institute of Iran  Tehran Iran"},{"name":"Department of Influenza and other Respiratory Viruses Pasteur Institute of Iran  Tehran Iran"},{"name":"Rapid Response Team for Infectious Diseases Pasteur Institute of Iran  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehsan","family":"Mostafavi","sequence":"additional","affiliation":[{"name":"Rapid Response Team for Infectious Diseases Pasteur Institute of Iran  Tehran Iran"},{"name":"Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging Infectious Diseases Pasteur Institute of Iran  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-6955","authenticated-orcid":false,"given":"Mehdi","family":"Fazlalipour","sequence":"additional","affiliation":[{"name":"Rapid Response Team for Infectious Diseases Pasteur Institute of Iran  Tehran Iran"},{"name":"WHO Collaborating Center for Reference and Research on Rabies Pasteur Institute of Iran  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Salehi\u2010Vaziri","sequence":"additional","affiliation":[{"name":"COVID\u201019 National Reference Laboratory Pasteur Institute of Iran  Tehran Iran"},{"name":"Rapid Response Team for Infectious Diseases Pasteur Institute of Iran  Tehran Iran"},{"name":"Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory) Pasteur Institute of Iran  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,10]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.Regional Office for South\u2010East A. Combating emerging infectious diseases in the South\u2010East Asia region. New Delhi: WHO Regional Office for South\u2010East Asia;2005."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966\u2010842X(02)02428\u20109"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.34172\/ijhpm.2021.13"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm\u20102020\u20100240"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlpt.2021.100506"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u201059745\u2010181\u20109_1"},{"key":"e_1_2_10_8_1","unstructured":"CormanV BleickerT Br\u00fcninkS DrostenC LandtO KoopmansM et al.Diagnostic detection of Wuhan coronavirus 2019 by real\u2010time RT\u2010PCR. Geneva: World Health Organization.2020;13."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvaa029"},{"key":"e_1_2_10_10_1","unstructured":"Emergencies Preparedness WHH.Antigen\u2010detection in the diagnosis of SARS\u2010CoV\u20102 infection: WHO;2021. Available at:https:\/\/www.who.int\/publications\/i\/item\/antigen-detection-in-the-diagnosis-of-sars-cov-2infection-using-rapid-immunoassays"},{"issue":"25","key":"e_1_2_10_11_1","first-page":"241","article-title":"Weekly epidemiological record, 2021, vol. 96, 25 [full issue]","volume":"96","author":"World Health Organization = Organisation mondiale de la Sante","year":"2021","journal-title":"Weekly Epidemiological Record = Relev\u00e9 \u00e9pid\u00e9miologique hebdomadaire"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4915678"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2711.211565"},{"key":"e_1_2_10_14_1","unstructured":"Nat Res 2021 Multiplex testing helps provide critical insights as respiratory viruses surge"},{"key":"e_1_2_10_15_1","unstructured":"AziziK SoltaniA Jaber HashemiSA DorzabanH.First report ofAedes aegyptias a main vector of arboviruses in southern Iran.1398."}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.13232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T14:50:41Z","timestamp":1704984641000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.13232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/irv.13232"],"URL":"https:\/\/doi.org\/10.1111\/irv.13232","archive":["Portico"],"relation":{},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"type":"print","value":"1750-2640"},{"type":"electronic","value":"1750-2659"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13232"}}