{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:48:06Z","timestamp":1783471686270,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections worldwide, particularly in young children. In Bhutan, respiratory disease continues to be among the top 10 diseases of morbidity for several years. This study aimed to estimate the prevalence of RSV among hospitalized patients with severe acute respiratory infection (SARI) in Bhutan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Respiratory specimens were collected from SARI patients of all ages in 2016 and 2018 following influenza surveillance guidelines. Specimens were tested for influenza and RSV, human metapneumovirus, adenovirus, and human parainfluenza virus types 1, 2, and 3 using real\u2010time reverse\u2010transcription polymerase chain reaction assay. Descriptive statistics were used to analyze the result in STATA 16.1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Of the 1339 SARI specimens tested, 34.8% were positive for at least one viral pathogen. RSV was detected in 18.5% of SARI cases, followed by influenza in 13.4% and other respiratory viruses in 3%. The median age of SARI cases was 3 (IQR: 0.8\u201321\u2009years)\u00a0years. RSV detection was higher among children aged 0\u20136 (Adj OR: 3.03; 95% CI: 1.7\u20135.39) and 7\u201323\u2009months (Adj OR: 3.01; 95% CI: 1.77\u20135.12) compared with the children aged 5\u201315\u2009years. RSV was also associated with breathing difficulty (Adj OR: 1.73; 95% CI: 1.17\u20132.56) and pre\u2010existing lung disease, including asthma (Adj OR: 2.78; 95% CI: 0.99\u20137.8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Respiratory viruses were detected in a substantial proportion of SARI hospitalizations in Bhutan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13242","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T22:19:11Z","timestamp":1705529951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Respiratory syncytial virus among hospitalized patients of severe acute respiratory infection in Bhutan: Cross\u2010sectional study"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3876-9638","authenticated-orcid":false,"given":"Kunzang","family":"Dorji","sequence":"first","affiliation":[{"name":"National Influenza Centre, Royal Centers for Disease Control Ministry of Health  Thimphu Bhutan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pema","family":"Yuden","sequence":"additional","affiliation":[{"name":"National Influenza Centre, Royal Centers for Disease Control Ministry of Health  Thimphu Bhutan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara Devi","family":"Ghishing","sequence":"additional","affiliation":[{"name":"National Influenza Centre, Royal Centers for Disease Control Ministry of Health  Thimphu Bhutan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govinda","family":"Ghimeray","sequence":"additional","affiliation":[{"name":"ICT Unit Royal Centers for Disease Control, Ministry of Health  Thimphu Bhutan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-8912","authenticated-orcid":false,"given":"Chonticha","family":"Klungthong","sequence":"additional","affiliation":[{"name":"Department of Virology Armed Forces Research Institute of Medical Sciences  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7384-1175","authenticated-orcid":false,"given":"Sonam","family":"Wangchuk","sequence":"additional","affiliation":[{"name":"Royal Centers for Disease Control, Ministry of Health  Thimphu Bhutan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-4493","authenticated-orcid":false,"given":"Aaron","family":"Farmer","sequence":"additional","affiliation":[{"name":"Department of Virology Armed Forces Research Institute of Medical Sciences  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2011.09.020"},{"key":"e_1_2_12_3_1","unstructured":"WHO.Respiratory syncytial virus (RSV) disease [Internet].2022. 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