{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:12:39Z","timestamp":1778807559189,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>COVID\u201019 pandemic led to significant reductions in influenza detection worldwide, fueling debates on whether influenza truly ceased circulating in communities. The number of influenza cases decreased significantly in Japan, raising concerns about the potential risk of decreased immunity to influenza in the population. Our single\u2010center study aimed to investigate influenza trends before and during the COVID\u201019 pandemic in Tokyo, Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included patients of all ages who visited Tokyo Shinagawa Hospital between April 1, 2018, and March 31, 2023. Influenza and COVID\u201019 tests were conducted using Quick Navi\u2010Flu2 and polymerase chain reaction (PCR). We analyzed data from before and during the COVID\u201019 epidemic, based on patient background, hospitalization, and deaths, collected from medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 12\u2009577 influenza tests were conducted, with approximately 100 tests consistently performed each month even in the influenza off\u2010season. Throughout the observation period, 962 positive cases were identified. However, no cases were observed for 27\u2009months between March 2020 and November 2022. Influenza A cases were reobserved in December 2022, followed by influenza B cases in March 2023, similar to the influenza incidence reports from Tokyo. The positivity rate during the 2022\u20132023 winter season was lower than before the COVID\u201019 epidemic and decreased in elderly patients, with no hospitalizations or deaths observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This single\u2010center study provided actual trend data for influenza patients before and during COVID\u201019 outbreaks in Tokyo, which could offer insights into the potential impact and likelihood of influenza virus infection in Japan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13248","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T05:09:43Z","timestamp":1704431383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Surveillance of seasonal influenza viruses during the COVID\u201019 pandemic in Tokyo, Japan, 2018\u20132023, a single\u2010center study"],"prefix":"10.1111","volume":"18","author":[{"given":"Hidenori","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Shinagawa Hospital  Tokyo Japan"},{"name":"Department of Infection Control Tokyo Shinagawa Hospital  Tokyo Japan"},{"name":"Department of Respiratory Medicine St. Marianna University School of Medicine  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Nagamatsu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Shinagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Shinagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Toba","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Shinagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mio","family":"Toyama\u2010Kousaka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Shinagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Shinagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwa","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Shinagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Shinagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syunsuke","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Infection Control Tokyo Shinagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzuko","family":"Fukasawa","sequence":"additional","affiliation":[{"name":"Department of Infection Control Tokyo Shinagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaeyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Infection Control Tokyo Shinagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Infection Control Tokyo Shinagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Mineshita","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine St. Marianna University School of Medicine  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Shinkai","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Shinagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO.Flu net. 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Accessed November 30 2023.https:\/\/www.niid.go.jp\/niid\/images\/iasr\/2023\/11\/525r04f02.gif"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0272795"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13090"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.14131"},{"key":"e_1_2_10_11_1","unstructured":"Otsuka Pharmaceutical.Quick Navi\u2010Flu2 test kit pdf. Accessed April 6 2023.https:\/\/www.otsuka-elibrary.jp\/pdf_viewer\/index.html?f=\/file\/1067\/qf2bnotk.pdf"},{"key":"e_1_2_10_12_1","unstructured":"Ministry of Health Labor and Welfare.Clinical Management of Patients with COVID\u201019. Accessed November 17 2023.https:\/\/www.niph.go.jp\/h-crisis\/wp-content\/uploads\/2020\/07\/20200706103735_content_000646531.pdf"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2022.101149"},{"key":"e_1_2_10_14_1","unstructured":"Tokyo Metropolitan Infectious Disease Surveillance Center.Influenza outbreak status. Accessed April 6 2023.https:\/\/idsc.tmiph.metro.tokyo.lg.jp\/diseases\/flu\/flu\/"},{"key":"e_1_2_10_15_1","unstructured":"Tokyo Metropolitan Infectious Disease Surveillance Center.COVID\u201019 outbreak status. 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Accessed April 6 2023.https:\/\/www2.pref.iwate.jp\/~hp1353\/kansen\/influenza.html"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010023\u201008640\u2010y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr4450"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab922"},{"key":"e_1_2_10_24_1","unstructured":"Ministry of Health Labor and Welfare.Report on the 2022\/23 seasonal influenza vaccine. Accessed April 6 2023.https:\/\/www.mhlw.go.jp\/content\/10906000\/000985405.pdf"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2020.1009"},{"key":"e_1_2_10_26_1","unstructured":"National Institute of Infectious Diseases.Influenza and other respiratory viruses. Accessed August 26 2023.https:\/\/kansen-levelmap.mhlw.go.jp\/Byogentai\/Pdf\/data95j.pdf"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7150a4"}],"updated-by":[{"DOI":"10.1111\/irv.70063","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000}}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.13248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T03:42:21Z","timestamp":1706586141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.13248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/irv.13248"],"URL":"https:\/\/doi.org\/10.1111\/irv.13248","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.13248\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13248\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13248\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13248\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13248"}}