{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:29:18Z","timestamp":1785569358559,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR20\/00012"],"award-info":[{"award-number":["JR20\/00012"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00498"],"award-info":[{"award-number":["PI21\/00498"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/01640"],"award-info":[{"award-number":["PI21\/01640"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RH RH042953"],"award-info":[{"award-number":["RH RH042953"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["SGR 01324 Q5856414G"],"award-info":[{"award-number":["SGR 01324 Q5856414G"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["AAPMRC 2022\/OP"],"award-info":[{"award-number":["AAPMRC 2022\/OP"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to describe a cohort of hematologic patients with COVID\u201019 treated with antivirals early.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Non\u2010interventional chart review study. Comparison of baseline characteristics and outcomes in high\u2010risk hematologic patients treated with remdesivir between December 2021 and April 2022 versus those treated with nirmatrelvir\/ritonavir between May and August 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010three patients were analyzed. Forty\u2010two received remdesivir, and 41 nirmatrelvir\/ritonavir. Patients with remdesivir were younger, vaccinated with lower number of doses, and received prior corticosteroids less frequently and sotrovimab, hyperimmune plasma and corticosteroids more often. Viral shedding median (IQR) duration was 18 (13\u201323) and 11 (8\u201321) days in the remdesivir and nirmatrelvir\/ritonavir groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Median (IQR) Ct values before treatment were similar in both groups. Within 5\u2009days of treatment, median (IQR) Ct values were 26 (23\u201329) and 33 (30\u201337) in the remdesivir and nirmatrelvir\/ritonavir groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). All patients were hospitalized for remdesivir administration and only four (9.8%) in the nirmatrelvir\/ritonavir group. The overall outcomes in this cohort of COVID\u201019 patients with Omicron variant was good, as no patient needed oxygen or ICU admission. One patient in remdesivir group died from septic shock. No severe adverse event was recorded in both treatment groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with hematologic malignancies and non\u2010severe COVID\u201019 who received nirmatrelvir\/ritonavir experienced faster decrease in viral load and shorter viral shedding. Furthermore, besides the advantage of oral administration, nirmatrelvir\/ritonavir administration reduced the need of hospital admission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13264","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T01:45:27Z","timestamp":1710207927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Real\u2010Life Comparison of Antivirals for SARS\u2010CoV\u20102 Omicron Infection in Patients With Hematologic Malignancies"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4441-6318","authenticated-orcid":false,"given":"Tommaso Francesco","family":"Aiello","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Hospital Clinic of Barcelona\u2010IDIBAPS Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Peyrony","sequence":"additional","affiliation":[{"name":"Emergency Department, H\u00f4pital Saint Louis Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Chumbita","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Clinic of Barcelona\u2010IDIBAPS Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Monz\u00f3","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Clinic of Barcelona\u2010IDIBAPS Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Lopera","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Clinic of Barcelona\u2010IDIBAPS Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Puerta\u2010Alcalde","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Clinic of Barcelona\u2010IDIBAPS Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Magnano","sequence":"additional","affiliation":[{"name":"Department of Haematology, Hospital Clinic of Barcelona\u2010IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Fern\u00e1ndez\u2010Avil\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Haematology, Hospital Clinic of Barcelona\u2010IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genoveva","family":"Cuesta","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Clinic University of Barcelona, ISGLOBAL  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montse","family":"Tuset","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hospital Clinic of Barcelona\u2010IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Mensa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Clinic of Barcelona\u2010IDIBAPS Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Esteve","sequence":"additional","affiliation":[{"name":"Department of Haematology, Hospital Clinic of Barcelona\u2010IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angeles","family":"Marcos","sequence":"additional","affiliation":[{"name":"Department of Haematology, Hospital Clinic of Barcelona\u2010IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Soriano","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Clinic of Barcelona\u2010IDIBAPS Universitat de Barcelona  Barcelona Spain"},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Garcia\u2010Vidal","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Clinic of Barcelona\u2010IDIBAPS Universitat de Barcelona  Barcelona Spain"},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona  Barcelona 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