{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:47:02Z","timestamp":1772160422514,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T00:00:00Z","timestamp":1710633600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["75D30120C07986"],"award-info":[{"award-number":["75D30120C07986"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Although psychiatric disorders have been associated with reduced immune responses to other vaccines, it remains unknown whether they influence COVID\u201019 vaccine effectiveness (VE). This study evaluated risk of COVID\u201019 hospitalization and estimated mRNA VE stratified by psychiatric disorder status.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In a retrospective cohort analysis of the VISION Network in four US states, the rate of laboratory\u2010confirmed COVID\u201019\u2010associated hospitalization between December 2021 and August 2022 was compared across psychiatric diagnoses and by monovalent mRNA COVID\u201019 vaccination status using Cox proportional hazards regression.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 2,436,999 adults, 22.1% had \u22651 psychiatric disorder. The incidence of COVID\u201019\u2010associated hospitalization was higher among patients with any versus no psychiatric disorder (394 vs. 156 per 100,000 person\u2010years,\n p<\/jats:italic>\n \u2009<\u20090.001). Any psychiatric disorder (adjusted hazard ratio [aHR], 1.27; 95% CI, 1.18\u20131.37) and mood (aHR, 1.25; 95% CI, 1.15\u20131.36), anxiety (aHR, 1.33, 95% CI, 1.22\u20131.45), and psychotic (aHR, 1.41; 95% CI, 1.14\u20131.74) disorders were each significant independent predictors of hospitalization. Among patients with any psychiatric disorder, aHRs for the association between vaccination and hospitalization were 0.35 (95% CI, 0.25\u20130.49) after a recent second dose, 0.08 (95% CI, 0.06\u20130.11) after a recent third dose, and 0.33 (95% CI, 0.17\u20130.66) after a recent fourth dose, compared to unvaccinated patients. Corresponding VE estimates were 65%, 92%, and 67%, respectively, and were similar among patients with no psychiatric disorder (68%, 92%, and 79%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Psychiatric disorders were associated with increased risk of COVID\u201019\u2010associated hospitalization. However, mRNA vaccination provided similar protection regardless of psychiatric disorder status, highlighting its benefit for individuals with psychiatric disorders.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/irv.13269","type":"journal-article","created":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T21:29:16Z","timestamp":1710710956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of COVID\u201019 Hospitalization and Protection Associated With mRNA Vaccination Among US Adults With Psychiatric Disorders"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2164-1726","authenticated-orcid":false,"given":"Matthew E.","family":"Levy","sequence":"first","affiliation":[{"name":"Westat Rockville Maryland USA"},{"name":"Helix San Mateo California 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