{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:30:54Z","timestamp":1791325854603,"version":"4.3.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:00:00Z","timestamp":1713657600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023280","name":"Seqirus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adults \u2265\u200965\u2009years of age have suboptimal influenza vaccination responses compared to younger adults due to age\u2010related immunosenescence. Two vaccines were specifically developed to enhance protection: MF59\u2010adjuvanted trivalent influenza vaccine (aIIV3) and high\u2010dose egg\u2010based trivalent influenza vaccine (HD\u2010IIV3e).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a retrospective cohort study conducted using US electronic medical records linked to claims data during the 2019\u20132020 influenza season, we compared the relative vaccine effectiveness (rVE) of aIIV3 with HD\u2010IIV3e and a standard\u2010dose non\u2010adjuvanted egg\u2010based quadrivalent inactivated influenza vaccine (IIV4e) for the prevention of cardiorespiratory hospitalizations, including influenza hospitalizations. We evaluated outcomes in the \u201cany\u201d diagnosis position and the \u201cadmitting\u201d position on the claim. A doubly robust methodology using inverse probability of treatment weighting and logistic regression was used to adjust for covariate imbalance. rVE was calculated as 100\u2009*\u2009(1\u2009\u2212\u2009OR\n                      <jats:sub>adjusted<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 4,299,594 adults \u2265\u200965\u2009years of age who received aIIV3, HD\u2010IIV3e, or IIV4e. Overall, aIIV3 was associated with lower proportions of cardiorespiratory hospitalizations with diagnoses in any position compared to HD\u2010IIV3e (rVE\u2009=\u20093.9% [95% CI, 2.7\u20135.0]) or IIV4e (9.0% [95% CI, 7.7\u201310.4]). Specifically, aIIV3 was more effective compared with HD\u2010IIV3e and IIV4e in preventing influenza hospitalizations (HD\u2010IIV3e: 9.7% [95% CI, 1.9\u201317.0]; IIV4e: 25.3% [95% CI, 17.7\u201332.2]). Consistent trends were observed for admitting diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Relative to both HD\u2010IIV3e and IIV4e, aIIV3 provided improved protection from cardiorespiratory or influenza hospitalizations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13288","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:33:18Z","timestamp":1713745998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Relative Effectiveness of the MF59\u00ae\u2010Adjuvanted Influenza Vaccine Versus High\u2010Dose and Non\u2010Adjuvanted Influenza Vaccines in Preventing Cardiorespiratory Hospitalizations During the 2019\u20132020 US Influenza Season"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-0182","authenticated-orcid":false,"given":"Mahrukh","family":"Imran","sequence":"first","affiliation":[{"name":"CSL Seqirus Inc.  Kirkland Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5783-0409","authenticated-orcid":false,"given":"Joan","family":"Puig\u2010Barbera","sequence":"additional","affiliation":[{"name":"FISABIO  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin\u00a0R.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Lopez\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Veradigm  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Dean","sequence":"additional","affiliation":[{"name":"Veradigm  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machaon","family":"Bonafede","sequence":"additional","affiliation":[{"name":"Veradigm  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mendel\u00a0D.\u00a0M.","family":"Haag","sequence":"additional","affiliation":[{"name":"CSL Seqirus Netherlands B. 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