{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:42:14Z","timestamp":1790095334536,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nonpharmaceutical interventions (NPIs) targeted at SARS\u2010CoV\u20102 have remarkably affected the circulation of other respiratory pathogens, including respiratory syncytial virus (RSV). This study aimed to assess the changes in epidemiological and clinical characteristics of RSV infections in hospitalized children before and during the pandemic in Suzhou, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively enrolled children aged &lt;\u200918\u2009years who were hospitalized in Soochow University Affiliated Children's Hospital with acute lower respiratory infection (ALRIs) from January 2018 to July 2022. Changes in epidemiological and clinical characteristics of RSV infections were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the same period in 2018\u20132019, the difference in the overall positive rate of RSV was not statistically significant in 2020, while it increased significantly in 2021 (11.8% [662\/5621] vs. 20.8% [356\/1711],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 2022 (9.0% [308\/3406] vs. 18.9% [129\/684],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Specifically, the positive rates declined considerably from October to December 2020 but sharply increased during the summer of 2021. Compared to prepandemic period, RSV infections were more frequently observed in older children during the pandemic. RSV\u2010positive children exhibited milder clinical characteristics during the COVID\u201019 pandemic, including decreased proportion of patients with hospital stay \u2265\u200911\u2009days (10.3% vs. 6.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), less requirement for oxygen therapy (13.7% vs. 6.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and fewer cases of polypnea (12.2% vs. 9.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and wheeze (50.1% vs. 42.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The implementation of multilayered NPIs targeted at COVID\u201019 has affected the activity of RSV. Ongoing monitoring of RSV is warranted as the changing RSV epidemiology can provide valuable insights for future healthcare system planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13291","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T23:03:10Z","timestamp":1713913390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of COVID\u201019 Nonpharmaceutical Interventions on Respiratory Syncytial Virus Infections in Hospitalized Children"],"prefix":"10.1111","volume":"18","author":[{"given":"Yingfeng","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Soochow University Affiliated Children's Hospital  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9974-6416","authenticated-orcid":false,"given":"Shaolong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Shao","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Soochow University Affiliated Children's Hospital  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Soochow University Affiliated Children's Hospital  Suzhou 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