{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:20:06Z","timestamp":1785363606312,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) is a substantial cause of infant morbidity and mortality due to seasonal peaks of bronchiolitis across the United States. Clinical and viral surveillance plays a pivotal role in helping hospital systems prepare for expected surges in RSV bronchiolitis. Existing surveillance efforts have shown a geographic pattern of RSV positivity across the United States, with cases typically starting in the southeast and spreading north and west. Public health measures implemented due to the COVID\u201019 pandemic disrupted viral transmission across the nation and altered the expected seasonality of RSV. The impact of these changes on the geographic progression of infant RSV bronchiolitis across the United States has not been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we used clinical and viral surveillance data from four health care systems located in different regions of the United States to describe the geographic progression of infant RSV bronchiolitis across the country from 2015 to 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prior to widespread circulation of SARS\u2010CoV\u20102, infant RSV bronchiolitis followed an established geographic pattern associated with seasonal epidemics originating in Florida and spreading north (North Carolina and New York) and later westward (Nevada). Although public health and social measures implemented during the COVID\u201019 pandemic disrupted the seasonality of RSV disease, infant RSV bronchiolitis epidemics progressed across the nation in a pattern identical to the prepandemic era.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings highlight the importance of ongoing clinical and viral surveillance to optimally track the onset of RSV epidemics and allow health care systems to prepare for expected RSV bronchiolitis surges.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13298","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T01:58:21Z","timestamp":1715824701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Geographic Progression of Infant Respiratory Syncytial Virus Associated Bronchiolitis Across the United States Before and Since the Onset of COVID\u201019: Results From Four Health Systems, 2015\u20132023"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6363-3089","authenticated-orcid":false,"given":"Adam\u00a0Z.","family":"Blatt","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases Duke University Health System  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Suh","sequence":"additional","affiliation":[{"name":"EpidStrategies, A Division of ToxStrategies  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Emmanuel\u00a0B.","family":"Walter","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Duke University Health System  Durham North Carolina USA"},{"name":"Duke Human Vaccine Institute  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles\u00a0T.","family":"Wood","sequence":"additional","affiliation":[{"name":"General Pediatrics and Adolescent Health Duke University Health System  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases University of South Florida Health  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u00a0E.","family":"Enriquez\u2010Bruce","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases University of South Florida Health  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Domachowske","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases State University of New York Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Daniels","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases State University of New York Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Budhecha","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Renown Health  Reno Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Elliott","sequence":"additional","affiliation":[{"name":"University of Nevada, Reno School of Medicine  Nevada Reno USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Wolf","sequence":"additional","affiliation":[{"name":"Clinetic  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emory\u00a0B.","family":"Waddell","sequence":"additional","affiliation":[{"name":"Clinetic  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naimisha","family":"Movva","sequence":"additional","affiliation":[{"name":"EpidStrategies, A Division of ToxStrategies  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Reichert","sequence":"additional","affiliation":[{"name":"EpidStrategies, A Division of ToxStrategies  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon\u00a0P.","family":"Fryzek","sequence":"additional","affiliation":[{"name":"EpidStrategies, A Division of ToxStrategies  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher\u00a0B.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Sanofi  Swiftwater Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00478-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac120"},{"key":"e_1_2_8_4_1","unstructured":"\u201cACIP Evidence to Recommendations for Use of Pfizer RSVpreF in Pregnant People \u201d (2023) accessed February 14 2024 https:\/\/www.cdc.gov\/vaccines\/acip\/recs\/grade\/pfizer\u2010RSVpreF\u2010pregnant\u2010people\u2010etr.html."},{"key":"e_1_2_8_5_1","unstructured":"\u201cACIP Evidence to Recommendations for Use of Nirsevimab in Children 8\u201319 Months of Age at Increased Risk of Severe Disease Entering Their Second RSV Season \u201d (2023) accessed October 18 2023 https:\/\/www.cdc.gov\/vaccines\/acip\/recs\/grade\/nirsevimab\u2010season2\u2010rsv\u2010infants\u2010children\u2010etr.html."},{"key":"e_1_2_8_6_1","unstructured":"\u201cACIP Evidence to Recommendations for Use of Nirsevimab in Infants Born During the RSV Season or Entering Their First RSV Season \u201d (2023) accessed October 18 2023 https:\/\/www.cdc.gov\/vaccines\/acip\/recs\/grade\/nirsevimab\u2010season1\u2010rsv\u2010infants\u2010children\u2010etr.html."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac220"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12885"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6702a4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.12788\/jhm.3608"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7214a1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004101"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054445"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2018.23.5.17-00284"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-4882-6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2022.27.16.2100619"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004591"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004101"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.13298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T06:07:44Z","timestamp":1727762864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.13298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/irv.13298"],"URL":"https:\/\/doi.org\/10.1111\/irv.13298","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.13298\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13298\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13298\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13298\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13298\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13298\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13298\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13298\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13298\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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