{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T22:08:10Z","timestamp":1775254090286,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Influenza may contribute to coronary\/cerebrovascular events and exacerbate underlying conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used self\u2010controlled case series (SCCS) design to analyze data from US Veterans \u226518\u2009years with coronary\/cerebrovascular or exacerbation event +\/\u22121\u2009year of lab\u2010confirmed influenza (LCI) during 2010\u20132018. We estimated the incidence ratio (IR) (95% CI) of the event for risk interval (Days 1\u20137 post\u2010LCI) versus control interval (all other times +\/\u22121\u2009year of LCI) with fixed\u2010effects conditional Poisson regression. We included biomarker data for mediation analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 3439 episodes with coronary\/cerebrovascular\u2010related hospitalizations. IRs (95% CI) for LCI risk versus control interval were STEMI 0.6 (0.1, 4.4), NSTEMI 7.3 (5.8, 9.2), ischemic stroke 4.0 (3.0, 5.4), hemorrhagic stroke 6.2 (3.4, 11.5), and coronary spasm 1.3 (0.5, 3.0). IR significantly increased for NSTEMI and ischemic stroke among those \u2265\u200965\u2009years. IR for NSTEMI and ischemic stroke dropped 26% and 10%, respectively, when white blood cell (WBC) and platelet count were considered. LCI was significantly associated with exacerbation of preexisting asthma, chronic obstructive pulmonary disease, and congestive heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found significant association between LCI and hospitalization for NSTEMI, ischemic stroke, and hemorrhagic stroke, the latter possibly due to unaccounted time\u2010varying confounding in SCCS design.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13304","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T02:43:30Z","timestamp":1717728210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Coronary and Cerebrovascular Events and Exacerbation of Existing Conditions After Laboratory\u2010Confirmed Influenza Infection Among US Veterans: A Self\u2010Controlled Case Series Study"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8598-5176","authenticated-orcid":false,"given":"Caroline","family":"Korves","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Program Veterans Affairs Medical Center  White River Junction Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabin","family":"Neupane","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Veterans Affairs Medical Center  White River Junction Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Smith","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Veterans Affairs Medical Center  White River Junction Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinong","family":"Young\u2010Xu","sequence":"additional","affiliation":[{"name":"PBM, Center for Medication Safety US Department of Veterans Affairs  Hines Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3025-7811","authenticated-orcid":false,"given":"Robertus","family":"van Aalst","sequence":"additional","affiliation":[{"name":"Department of Health Services, Policy, and Practice Brown University School of Public Health  Providence Rhode Island USA"},{"name":"Global Medical Evidence Generation Sanofi  Swiftwater Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salaheddin\u00a0M.","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Vaccine and Drug Evaluation Centre, Department of Community Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8100-465X","authenticated-orcid":false,"given":"Matthew\u00a0M.","family":"Loiacono","sequence":"additional","affiliation":[{"name":"Global Medical Evidence Generation Sanofi  Swiftwater Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"CDC \u201cInfluenza: Disease Burden of Flu \u201d accessed May 5 2023 https:\/\/www.cdc.gov\/flu\/about\/burden\/index.html."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20-1509"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2491-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.0433"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartjsupp\/suac122"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01794-2017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702090"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243248"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.17.1900199"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis597"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041747"},{"key":"e_1_2_9_13_1","unstructured":"Department of VA VHA \u201cSecondary Veterans Health Administration \u201d accessed April 3 2023 https:\/\/www.va.gov\/health\/."},{"key":"e_1_2_9_14_1","unstructured":"Center for Disease Control and Prevention \u201cNational Center for Health Statistics: International Classification of Diseases (ICD\u201010\u2010CM\/PCS) Transition \u2013 Background \u201d accessed May 5 2023 https:\/\/www.cdc.gov\/nchs\/icd\/icd10cm_pcs_background.htm."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2302"},{"key":"e_1_2_9_16_1","first-page":"415","article-title":"Etiology of Thrombocytosis in a General Medicine Population: Analysis of 801 Cases With Emphasis on Infectious Causes","volume":"4","author":"Rose S. 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