{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:14:06Z","timestamp":1791951246547,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01AI151810"],"award-info":[{"award-number":["U01AI151810"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The newly emerged SARS\u2010CoV\u20102 possesses shared antigenic epitopes with other human coronaviruses. We investigated if COVID\u201019 vaccination or SARS\u2010CoV\u20102 infection may boost cross\u2010reactive antibodies to other human coronaviruses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prevaccination and postvaccination sera from SARS\u2010CoV\u20102 na\u00efve healthy subjects who received three doses of the mRNA vaccine (BioNTech, BNT) or the inactivated vaccine (CoronaVac, CV) were used to monitor the level of cross\u2010reactive antibodies raised against other human coronaviruses by enzyme\u2010linked immunosorbent assay. In comparison, convalescent sera from COVID\u201019 patients with or without prior vaccination history were also tested. Pseudoparticle neutralization assay was performed to detect neutralization antibody against MERS\u2010CoV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among SARS\u2010CoV\u20102 infection\u2212na\u00efve subjects, BNT or CV significantly increased the anti\u2010S2 antibodies against Betacoronaviruses (OC43 and MERS\u2010CoV) but not Alphacoronaviruses (229E). The prevaccination antibody response to the common cold human coronaviruses did not negatively impact the postvaccination antibody response to SARS\u2010CoV\u20102. Cross\u2010reactive antibodies that binds to the S2 protein of MERS\u2010CoV were similarly detected from the convalescent sera of COVID\u201019 patients with or without vaccination history. However, these anti\u2010S2 antibodies do not possess neutralizing activity in MERS\u2010CoV pseudoparticle neutralization tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that SARS\u2010CoV\u20102 infection or vaccination may potentially modulate population immune landscape against previously exposed or novel human coronaviruses. The findings have implications for future sero\u2010epidemiological studies on MERS\u2010CoV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13309","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:50Z","timestamp":1715299250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cross\u2010Reactive Antibody Responses to Coronaviruses Elicited by SARS\u2010CoV\u20102 Infection or Vaccination"],"prefix":"10.1111","volume":"18","author":[{"given":"Richard\u00a0S.\u00a0H.","family":"Lee","sequence":"first","affiliation":[{"name":"School of Public Health, LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel\u00a0M.\u00a0S.","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Public Health, LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Public Health, LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie\u00a0Y.\u00a0S.","family":"Tsoi","sequence":"additional","affiliation":[{"name":"School of Public Health, LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaman\u00a0K.\u00a0M.","family":"Lau","sequence":"additional","affiliation":[{"name":"School of Public Health, LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CoCo\u00a0H.\u00a0C.","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Public Health, LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u00a0K.\u00a0C.","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0S.\u00a0C.","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics CUHK, Prince of Wales Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik","family":"Peiris","sequence":"additional","affiliation":[{"name":"School of Public Health, LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"},{"name":"Centre for Immunology &amp; Infection Hong Kong Science Park  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-3609","authenticated-orcid":false,"given":"Hui\u2010Ling","family":"Yen","sequence":"additional","affiliation":[{"name":"School of Public Health, LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0118-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2020.104490"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe1107"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.02.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.12.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110169"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04186-8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27674-x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111022"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-10230-y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75228"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23977-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00809-x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-021-00369-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02219-5"},{"issue":"36","key":"e_1_2_10_18_1","article-title":"Seroepidemiology for MERS Coronavirus Using Microneutralisation and Pseudoparticle Virus Neutralisation Assays Reveal a High Prevalence of Antibody in Dromedary Camels in Egypt, June 2013","volume":"18","author":"Perera R. A.","year":"2013","journal-title":"Euro Surveillance"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02250-23","article-title":"The Post\u2010COVID\u201019 Population Has a High Prevalence of Cross\u2010Reactive Antibodies to Spikes From All Orthocoronavirinae Genera","volume":"15","author":"Singh G.","year":"2023","journal-title":"MBio"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-021-00596-4"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq3773"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23074-3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.02.005"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj3321"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.13309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T06:07:09Z","timestamp":1727762829000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.13309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/irv.13309"],"URL":"https:\/\/doi.org\/10.1111\/irv.13309","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.13309\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13309\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13309\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13309\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13309\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13309\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13309\/v1\/review2","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2024-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13309"}}