{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:09:52Z","timestamp":1773144592537,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["IP001078"],"award-info":[{"award-number":["IP001078"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["IP001083"],"award-info":[{"award-number":["IP001083"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002243"],"award-info":[{"award-number":["UL1 TR002243"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Understanding how symptoms are associated with SARS\u2010CoV\u20102 culture positivity is important for isolation and transmission control guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Individuals acutely infected with SARS\u2010CoV\u20102 in Tennessee and their household contacts were recruited into a prospective study. All participants self\u2010collected nasal swabs daily for 14\u2009days and completed symptom diaries from the day of illness onset through day 14 postenrollment. Nasal specimens were tested for SARS\u2010CoV\u20102 using RT\u2010qPCR. Positive specimens with cycle threshold values &lt;\u200940 were sent to the Centers for Disease Control and Prevention (CDC) for viral culture. First, we modeled the association between symptoms and the risk of culture positivity using an age\u2010adjusted generalized additive model (GAM) accounting for repeated measurements within participants and a symptom\u2010day spline. Next, we investigated how timing of symptom resolution was associated with the timing of culture resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In a GAM restricted to follow\u2010up days after symptoms began, the odds of a specimen being culture positive was significantly increased on days when wheezing, loss of taste or smell, runny nose, nasal congestion, sore throat, fever, or any symptom were reported. For all symptoms except sore throat, it was more common for participants to have culture resolution before symptom resolution than for culture to resolve after or on the same day as symptom resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, symptomatic individuals were more likely to be SARS\u2010CoV\u20102 viral culture positive. For most symptoms, culture positivity was more likely to end before symptoms resolved. However, a proportion of individuals remained culture positive after symptom resolved, across all symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13318","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T07:56:01Z","timestamp":1718956561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Symptoms and Viral Culture Positivity for SARS\u2010CoV\u20102\u2014Tennessee, April\u2013July 2020"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-8698","authenticated-orcid":false,"given":"Jessica\u00a0E.","family":"Biddle","sequence":"first","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaston","family":"Bonenfant","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos\u00a0G.","family":"Grijalva","sequence":"additional","affiliation":[{"name":"Department of Health Policy Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Biomedical Informatics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha\u00a0B.","family":"Halasa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James\u00a0D.","family":"Chappell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6756-1425","authenticated-orcid":false,"given":"Alexandra","family":"Mellis","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie","family":"Reed","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u00a0Keipp","family":"Talbot","sequence":"additional","affiliation":[{"name":"Department of Health Policy Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-9941","authenticated-orcid":false,"given":"Melissa\u00a0A.","family":"Rolfes","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"\u201cSymptoms of COVID\u201019 \u201d (2023) 2022 [cited 2023 January 25] https:\/\/www.cdc.gov\/coronavirus\/2019\u2010ncov\/symptoms\u2010testing\/symptoms.html."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6930e1"},{"key":"e_1_2_8_4_1","unstructured":"\u201cIsolation and Precautions for People With COVID\u201019 \u201d (2023) 2023 [cited 2023 August 30] https:\/\/www.cdc.gov\/coronavirus\/2019\u2010ncov\/your\u2010health\/isolation.html."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiad018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6944e1"},{"key":"e_1_2_8_7_1","unstructured":"\u201cCDC 2019\u2010Novel Coronavirus (2019\u2010nCoV) Real\u2010Time RT\u2010PCR Diagnostic Panel \u201d (2020) https:\/\/www.fda.gov\/media\/134922\/download."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2010.12.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac282"},{"key":"e_1_2_8_10_1","volume-title":"R: A Language and 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M.Mellis A. S.Lauring H. K.Talbot et\u00a0al. \u201cChanges in Transmission and Symptoms of SARS\u2010CoV\u20102 in United States Households April 2020\u2013September 2022 \u201d medRxiv (2023) 2023\/290185."}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.13318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T14:53:20Z","timestamp":1720536800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.13318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/irv.13318"],"URL":"https:\/\/doi.org\/10.1111\/irv.13318","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.13318\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13318\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13318\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13318\/v2\/response1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2023-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13318"}}