{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:25:06Z","timestamp":1753878306205,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31CA30_196544","PZ00P3_179919"],"award-info":[{"award-number":["31CA30_196544","PZ00P3_179919"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is debate about the causes of the recent birth rate decline in high\u2010income countries worldwide. During the pandemic, concern about the effects on reproductive health has caused vaccine hesitancy. We investigated the association of SARS\u2010CoV\u20102 vaccination and infection with involuntary childlessness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Females in fertility age within a prospective multicenter cohort of healthcare workers (HCW) were followed since August 2020. Data on baseline health, SARS\u2010CoV\u20102\u2010infection, and vaccination were obtained and regularly updated, in which serum samples were collected repetitively and screened for anti\u2010nucleocapsid and anti\u2010spike antibodies. In October 2023, participants indicated the presence of involuntary childlessness with onset during the pandemic, whereas those indicating an onset before the pandemic were excluded. The association of involuntary childlessness and SARS\u2010CoV\u20102\u2010vaccination and infection was investigated using univariable and multivariable analysis. Sensitivity analysis was performed to compare those reporting involuntary childlessness with those birthing a child since 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 798 participants, 26 (3.2%) reported involuntary childlessness starting since the pandemic. Of the involuntary childless women, 73.1% (19\/26) were vaccinated compared to 86.0% (664\/772) without involuntary childlessness (<jats:italic>p<\/jats:italic>\u2009=\u20090.73). SARS\u2010CoV\u20102 infection was reported by 76.9% (20\/26) compared to 72.4% (559\/772) of controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.64). Neither SARS\u2010CoV\u20102 vaccination (aOR 0.91 per dose, 95%CI 0.67\u20131.26) nor infection (aOR per infection 1.05, 95%CI 0.62\u20131.71) was associated with involuntary childlessness. Sensitivity analysis confirmed these results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among female HCW of fertility age, 3.2% indicated involuntary childlessness, which is comparable to pre\u2010pandemic data. No association between involuntary childlessness and SARS\u2010CoV\u20102 vaccination or infection was found.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.13333","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T06:53:41Z","timestamp":1717743221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SARS\u2010CoV\u20102 Vaccination is Not Associated With Involuntary Childlessness in Female Healthcare Workers: A Multicenter Cohort Study"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6033-1037","authenticated-orcid":false,"given":"Tamara","family":"D\u00f6rr","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology Cantonal Hospital St Gallen  St Gallen 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Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Gr\u00e4ssli","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology Cantonal Hospital St Gallen  St Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsbeth","family":"Betschon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Clienia Littenheid  Littenheid Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u00a0Carsten","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Center for Neurological Rehabilitation  Zihlschlacht Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Ortner","sequence":"additional","affiliation":[{"name":"Rheintal Werdenberg Sarganserland Hospital Group  Grabs 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