{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:47:03Z","timestamp":1772160423398,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute respiratory infections (ARIs) are a major healthcare issue in children. The SARS\u2010CoV\u20102 pandemic changed the epidemiology of ARIs; the aims of this study are to characterize the epidemiological trend of ARI emergency hospitalizations and virology results and to estimate the association of ARI emergency hospitalizations with respiratory viruses from January 2018 to June 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was carried out in an Italian tertiary care children's hospital (Bambino Ges\u00f9 Children's Hospital). The demographic and clinical information of children who accessed the Emergency Department (ED) with ARI and were hospitalized were retrospectively extracted from the electronic health records. Multivariate linear regression model was used to compare the number of ARI hospital admissions with the reported temporal trends in viruses diagnosed from respiratory samples throughout the same time period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, there were 92,140 ED visits and 10,541 hospitalizations due to ARIs, reflecting an admission rate of 11.4%. The highest proportion of hospitalizations occurred in infants \u2264\u20091\u2009year of age (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094840, 45.9% of total admissions), with a hospitalization rate of 22.6%. Emergency hospitalizations aligned closely with the predictions made by the multivariate regression model; peaks in hospitalizations reflected Respiratory Syncytial Virus (RSV) circulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ARI hospital urgent admissions are a relevant component of ARI disease burden in children. RSV prevention and control are crucial to limit the risk of urgent hospitalizations due to ARIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.13335","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T04:08:28Z","timestamp":1718683708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of SARS\u2010CoV\u20102 Pandemic on Emergency Hospitalizations for Acute Respiratory Infections: The Experience of a Paediatric Tertiary Care Hospital in Italy"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6492-4497","authenticated-orcid":false,"given":"Marta\u00a0Luisa","family":"Ciofi\u00a0degli\u00a0Atti","sequence":"first","affiliation":[{"name":"Epidemiology, Clinical Pathways and Clinical Risk Unit Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Beccia","sequence":"additional","affiliation":[{"name":"Epidemiology, Clinical Pathways and Clinical Risk Unit Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"},{"name":"University Department of Life Sciences and Public Health Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2874-7563","authenticated-orcid":false,"given":"Carmen","family":"D'Amore","sequence":"additional","affiliation":[{"name":"Epidemiology, Clinical Pathways and Clinical Risk Unit Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucilla","family":"Rav\u00e0","sequence":"additional","affiliation":[{"name":"Epidemiology, Clinical Pathways and Clinical Risk Unit Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-2541","authenticated-orcid":false,"given":"Paola","family":"Bernaschi","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Clinical Area Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Russo","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Clinical Area Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Villani","sequence":"additional","affiliation":[{"name":"University\u2010Hospital Paediatric Clinical Area Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo\u00a0Federico","family":"Perno","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Clinical Area Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Raponi","sequence":"additional","affiliation":[{"name":"Medical Direction Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)61901\u20101"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(18)30408\u2010X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10344"},{"key":"e_1_2_11_5_1","unstructured":"\u201cThe State of the World's Children 2023|UNICEF \u201d2023 Accessed January 9 2024 https:\/\/www.unicef.org\/reports\/state\u2010worlds\u2010children\u20102023."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.716351"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019\u20102614"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012\u20103877"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31829b7e43"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014\u20102742"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192315443"},{"key":"e_1_2_11_12_1","unstructured":"\u201cWHO Director\u2010General's Opening Remarks at The Media Briefing \u2013 5 May 2023 \u201d Accessed January 2 2024 https:\/\/www.who.int\/director\u2010general\/speeches\/detail\/who\u2010director\u2010general\u2010s\u2010opening\u2010remarks\u2010at\u2010the\u2010media\u2010briefing\u2010\u2010\u20105\u2010may\u20102023."},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlpt.2020.08.019"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010022\u201007041\u2010x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.11.039"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243694"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002811"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9081242"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2022.01.010"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13102"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201084423\u20102"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piy046"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002681"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052\u2010022\u201001221\u2010w"},{"issue":"4","key":"e_1_2_11_25_1","first-page":"233","article-title":"Crowding and Delivery of Healthcare in Emergency Departments: The European Perspective","volume":"10","author":"Jayaprakash N.","year":"2009","journal-title":"The Western Journal of Emergency Medicine"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo\u20102020\u2010000862"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)01733\u20105"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.7416\/ai.2022.2548"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922817730346"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acap.2014.01.004"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e3181ab78c7"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.13244"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.41779"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15040934"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15122425"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.15117"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705\u2010023\u201005698\u20106"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12135"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985\u2010021\u201001627\u20108"},{"key":"e_1_2_11_40_1","unstructured":"Rapporto Epidemiologico Influnet \u201cStagione Influenzale 2019\u20132020. Settimana 2020\u201317 dal 20 al 26 aprile 2020 \u201d Rapporto N. 24 del 8 maggio 2020 https:\/\/www.salute.gov.it\/portale\/temi\/documenti\/epidemiologica\/Influnet_2020_17.pdf."},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2021.26.22.2001160"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2021.10.022"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7029a1"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13103"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2022.10.001"},{"key":"e_1_2_11_46_1","unstructured":"\u201cRespiVirNet \u2010 rapporto sorveglianza virologica 2022\u20102023 \u201dhttps:\/\/www.salute.gov.it\/portale\/temi\/documenti\/virologica\/Influnet_Virol_2023_17.pdf."},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010022\u201007262\u20100"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac373"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20104642(22)00321\u20102"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2216480"},{"key":"e_1_2_11_51_1","unstructured":"\u201cFirst RSV Vaccine to Protect Infants up to 6 Months of Age and Older Adults|European Medicines Agency \u201d Accessed January 31 2024 https:\/\/www.ema.europa.eu\/en\/news\/first\u2010rsv\u2010vaccine\u2010protect\u2010infants\u20106\u2010months\u2010age\u2010and\u2010older\u2010adults."}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.13335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T14:53:43Z","timestamp":1720536823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.13335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/irv.13335"],"URL":"https:\/\/doi.org\/10.1111\/irv.13335","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.13335\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13335\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13335\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.13335\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2024-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13335"}}