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In dried blood spot (DBS) collected within 5\u2009days of illness onset and during convalescence, we measured binding antibody (bAb) against ancestral spike protein receptor binding domain (RBD) and nucleocapsid (N) protein using a commercial multiplex bead assay. Geometric mean bAb concentrations against RBD increased by a factor of 2.5 from 1258 to 3189\u2009units\/mL and by a factor of 47 against N protein from 5.5 to 259\u2009units\/mL between acute illness and convalescence; lower concentrations were associated with greater geometric mean ratios. Paired DBS specimens may be used to evaluate humoral response to SARS\u2010CoV\u20102 infection.<\/jats:p>","DOI":"10.1111\/irv.13339","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T08:14:16Z","timestamp":1721117656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antibody Response to Symptomatic Infection With SARS\u2010CoV\u20102 Omicron Variant Viruses, December 2021\u2013June 2022"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-9501","authenticated-orcid":false,"given":"Ryan","family":"Sandford","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"},{"name":"Oak Ridge Institute for Science and Education  Oak Ridge Tennessee USA"},{"name":"Rollins School of Public Health  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Yadav","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma\u00a0K.","family":"Noble","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"},{"name":"Oak Ridge Institute for Science and Education  Oak Ridge Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4479-897X","authenticated-orcid":false,"given":"Kelsey","family":"Sumner","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devyani","family":"Joshi","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara\u00a0Y.","family":"Tartof","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California  Yorba Linda California USA"},{"name":"Department of Health Systems Science Kaiser Permanente Bernard J. 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