{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:58:19Z","timestamp":1789646299479,"version":"4.0.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:00:00Z","timestamp":1722729600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100021316","name":"AstraZeneca United States","doi-asserted-by":"publisher","award":["RSV00027"],"award-info":[{"award-number":["RSV00027"]}],"id":[{"id":"10.13039\/100021316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014588","name":"Sanofi Pasteur","doi-asserted-by":"publisher","award":["RSV00027"],"award-info":[{"award-number":["RSV00027"]}],"id":[{"id":"10.13039\/100014588","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Respiratory syncytial virus (RSV) is the most common cause of acute respiratory infections in young children. Limited data are available on RSV disease burden in primary care and emergency departments (EDs). This review synthesizes the evidence on population\u2010based incidence rates of RSV infections in young children (&lt;\u20095\u2009years) in primary care and EDs. A systematic literature review was performed in PubMed and Embase. Studies reporting yearly population\u2010based RSV incidence rates in primary care and EDs were included. A total of 4244 records were screened and 32 studies were included, conducted between 1993 and 2019. Studies were mainly performed in high\u2010income countries (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200927), with 15 studies in North America and 10 studies in Europe. There was significant variability in study methodology and setting among studies, resulting in considerable variability in reported incidence rates. Incidence rates were higher in primary care\u2014ranging from 0.8 to 330 (median\u2009=\u2009109) per 1000 population\u2014compared to EDs (7.5\u2013144.0, median\u2009=\u200948). The highest incidence rates were reported in infants. Additionally, incidence rates were higher in high\u2010income countries and in studies using laboratory\u2010confirmed RSV cases compared to studies using bronchiolitis ICD\u2010codes (non\u2013laboratory confirmed). Our study found that a substantial number of children under 5\u2009years of age attend primary care settings and EDs, every year for RSV infections. Due to the considerable heterogeneity in study methodology, it was impossible to draw definitive conclusions regarding factors explaining differences in reported incidence rates. Additionally, more studies in low\u2010 and middle\u2010income countries are recommended.\n                  <\/jats:p>","DOI":"10.1111\/irv.13344","type":"journal-article","created":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T22:53:55Z","timestamp":1722812035000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Disease Burden of RSV Infections and Bronchiolitis in Young Children (&lt;\u20095\u2009Years) in Primary Care and Emergency Departments: A Systematic Literature Review"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7267-0897","authenticated-orcid":false,"given":"Susanne","family":"Heemskerk","sequence":"first","affiliation":[{"name":"Netherlands Institute for Health Services Research (Nivel)  Utrecht The 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