{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:00:42Z","timestamp":1784761242390,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024784","name":"Institute for Basic Sciences, technology and Innovation, Pan African University","doi-asserted-by":"publisher","award":["IBS\u2010R801\u2010D1"],"award-info":[{"award-number":["IBS\u2010R801\u2010D1"]}],"id":[{"id":"10.13039\/501100024784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A5A2017476"],"award-info":[{"award-number":["2020R1A5A2017476"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Omicron variants have rapidly diversified into sublineages with mutations that enhance immune evasion, posing challenges for vaccination and antibody responses. This study aimed to compare serum cross\u2010neutralizing antibody responses against various SARS\u2010CoV\u20102 Omicron sublineages (BA.1, BA.5, XBB.1.17.1, FK.1.1, and JN.1) in recipients of monovalent COVID\u201019 boosters, bivalent booster recipients, and individuals who had recovered from Omicron BA.5 infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a micro\u2010neutralization assay on serum samples from monovalent BNT162b2 booster recipients (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200954), bivalent BNT162b2 booster recipients (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200924), and SARS\u2010CoV\u20102 Omicron BA.5\u2010recovered individuals (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200913). The history of SARS\u2010CoV\u20102 Omicron infection was assessed using ELISA against the SARS\u2010CoV\u20102 NP protein.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bivalent booster recipients exhibited significantly enhanced neutralization efficacy against Omicron sublineages compared to those who had received monovalent booster vaccinations. Omicron BA.5\u2010recovered individuals displayed similar neutralizing antibodies (NAbs) to the bivalent booster recipients. Despite the improved neutralization in bivalent recipients and BA.5\u2010recovered individuals, there were limitations in neutralization against the recently emerged Omicron subvariants: XBB.1.17.1 FK.1.1, and JN.1. In both monovalent and bivalent booster recipients, a history of Omicron breakthrough infection was associated with relatively higher geometric mean titers of NAbs against Omicron BA.1, BA.5, and XBB.1.17.1 variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study underscores the intricate interplay between vaccination strategies, immune imprinting, and the dynamic landscape of SARS\u2010CoV\u20102 variants. Although bivalent boosters enhance neutralization, addressing the challenge of emerging sublineages like XBB.1.17.1, FK.1.1, and JN.1 may necessitate the development of tailored vaccines, underscoring the need for ongoing adaptation to effectively combat this highly mutable virus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70000","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T13:07:59Z","timestamp":1728392879000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhancing Omicron Sublineage Neutralization: Insights From Bivalent and Monovalent COVID\u201019 Booster Vaccines and Recent SARS\u2010CoV\u20102 Omicron Variant Infections"],"prefix":"10.1111","volume":"18","author":[{"given":"Hye\u00a0Won","family":"Jeong","sequence":"first","affiliation":[{"name":"College of Medicine and Medical Research Institute Chungbuk National University  Cheongju Republic of Korea"},{"name":"Department of Internal Medicine Chungbuk National University Hospital  Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rare","family":"Rollon","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Research Institute Chungbuk National University  Cheongju Republic of Korea"},{"name":"Center for Study of Emerging and Re\u2010emerging Viruses Korea Virus Research Institute, Institute for Basic Science (IBS)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u2010Mi","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Study of Emerging and Re\u2010emerging Viruses Korea Virus Research Institute, Institute for Basic Science (IBS)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juryeon","family":"Gil","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Research Institute Chungbuk National University  Cheongju Republic of Korea"},{"name":"Center for Study of Emerging and Re\u2010emerging Viruses Korea Virus Research Institute, Institute for Basic Science (IBS)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00a0Anthony","family":"Casel","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Research Institute Chungbuk National University  Cheongju Republic of Korea"},{"name":"Center for Study of Emerging and Re\u2010emerging Viruses Korea Virus Research Institute, Institute for Basic Science (IBS)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunwoo","family":"Jang","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Research Institute Chungbuk National University  Cheongju Republic of Korea"},{"name":"Center for Study of Emerging and Re\u2010emerging Viruses Korea Virus Research Institute, Institute for Basic Science (IBS)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u00a0Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Research Institute Chungbuk National University  Cheongju Republic of Korea"},{"name":"Center for Study of Emerging and Re\u2010emerging Viruses Korea Virus Research Institute, Institute for Basic Science (IBS)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Gyu","family":"Jang","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Research Institute Chungbuk National University  Cheongju Republic of Korea"},{"name":"Center for Study of Emerging and Re\u2010emerging Viruses Korea Virus Research Institute, Institute for Basic Science (IBS)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josea\u00a0Carmel","family":"Lazarte","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Research Institute Chungbuk National University  Cheongju Republic of Korea"},{"name":"Center for Study of Emerging and Re\u2010emerging Viruses Korea Virus Research Institute, Institute for Basic Science (IBS)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Research Institute Chungbuk National University  Cheongju Republic of Korea"},{"name":"Department of Internal Medicine Chungbuk National University Hospital  Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u00a0Hyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungbuk National University 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