{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:58:12Z","timestamp":1792058292661,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This retrospective cohort study analyzed data from a Japanese health insurance database to assess the effectiveness of baloxavir (<jats:italic>n<\/jats:italic>\u2009=\u20094822) for preventing severe events compared with oseltamivir (<jats:italic>n<\/jats:italic>\u2009=\u200910,523) in patients with influenza B. The primary endpoint was hospitalization incidence (Days 2\u201314). The secondary endpoints included intravenous antibacterial drug use, pneumonia hospitalization, heart failure hospitalization, inhalational oxygen requirement, and use of other anti\u2010influenza drugs. The hospitalization incidence was significantly lower with baloxavir (0.15% vs. 0.37%; risk ratio: 2.48, 95% confidence interval: 1.13\u20135.43). Pneumonia and additional anti\u2010influenza therapy were also less frequent with baloxavir, thus supporting its use.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> UMIN Clinical Trials Registry Study ID: UMIN000051382<\/jats:p>","DOI":"10.1111\/irv.70002","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T08:38:40Z","timestamp":1724747920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of the Effectiveness of Baloxavir and Oseltamivir in Outpatients With Influenza B"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-5386","authenticated-orcid":false,"given":"Takahiro","family":"Takazono","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Hospital  Nagasaki Japan"},{"name":"Department of Infectious Diseases Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-4242","authenticated-orcid":false,"given":"Genta","family":"Ito","sequence":"additional","affiliation":[{"name":"Data Science Department, Shionogi &amp; Co., Ltd.  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Hosogaya","sequence":"additional","affiliation":[{"name":"Clinical Research Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Iwanaga","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Komeda","sequence":"additional","affiliation":[{"name":"Data Science Department, Shionogi &amp; Co., Ltd.  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Data Science Department, Shionogi &amp; Co., Ltd.  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitake","family":"Kitanishi","sequence":"additional","affiliation":[{"name":"Data Science Department, Shionogi &amp; Co., Ltd.  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Ogura","sequence":"additional","affiliation":[{"name":"Global Development Division, Shionogi &amp; Co., Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mukae","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Hospital  Nagasaki Japan"},{"name":"Department of Respiratory Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104970"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40506-016-0085-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0899-1"},{"key":"e_1_2_6_5_1","unstructured":"Roche \u201cRoche's Xofluza Approved by the European Commission for the Treatment of Influenza the First New Influenza Antiviral for Patients in Almost 20 Years \u201d (2021) https:\/\/www.roche.com\/media\/releases\/med\u2010cor\u20102021\u201001\u201011."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1870"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30004-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2019.12.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.15169"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.10.008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12862"},{"key":"e_1_2_6_12_1","volume-title":"Statistical Handbook of Japan 2022","author":"Statistics Bureau, Ministry of Internal Affairs and Communications","year":"2022"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141993"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.70002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T02:44:45Z","timestamp":1728614685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.70002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,27]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/irv.70002"],"URL":"https:\/\/doi.org\/10.1111\/irv.70002","archive":["Portico"],"relation":{},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,27]]},"assertion":[{"value":"2024-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70002"}}