{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:00:26Z","timestamp":1767772826117,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study is aimed at providing information about the timing of booster doses and antibody kinetics in healthcare workers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This research extends a prospective cohort study conducted at Dokuz Eylul University Hospital in Turkey, covering the period from March 2021 to December 2021. During this timeframe, the antibody levels of the health workers were measured at four different time points. The associations of antibody levels with gender, age, occupation, body mass index (BMI), chronic disease, and smoking were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant difference between antibody levels in all four blood draws (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Antibody levels decreased in both those vaccinated with BNT162b2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and those vaccinated with CoronaVac (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) until the fourth blood draw. There was a significant difference between those vaccinated with one and two doses of booster BNT162b2 before the third blood draw (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), which continued at the fourth blood draw (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The antibody levels of those with an interval of 41\u201350\u2009days between two vaccinations decreased significantly at the fourth blood draw (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides insight into the dynamics and persistence of antibody response after additional COVID\u201019 vaccine doses among healthcare workers. The longer the interval between booster doses may result in greater antibody levels being maintained over time, allowing for longer durations of protection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.70003","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T09:34:30Z","timestamp":1724751270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Waning Humoral Immune Response Following the Third and Fourth SARS\u2010COV\u20102 Vaccine: A Cohort Study in Healthcare Workers"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1383-3215","authenticated-orcid":false,"given":"Ahmet\u00a0Furkan","family":"S\u00fcner","sequence":"first","affiliation":[{"name":"Department of Public Health, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl","family":"Erg\u00f6r","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"\u00c7a\u011flayan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Diyarbak\u0131r Provincial Health Directorate  Diyarbakir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesli\u015fah","family":"T\u00fcre","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmak","family":"G\u00fczel","sequence":"additional","affiliation":[{"name":"Medical Microbiology Unit Mardin Nusaybin State Hospital  Mardin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7a\u011flar","family":"Irmak","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Clinical Microbiology Unit Hakkari Y\u00fcksekova State Hospital  Hakkari Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"I\u015f\u0131k","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zg\u00fcr","family":"Appak","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muammer","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sema\u00a0Alp","family":"\u00c7avu\u015f","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Sayiner","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alp","family":"Erg\u00f6r","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y\u00fccel","family":"Demiral","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Interim Recommendations for Use of the Pfizer\u2013BioNTech COVID\u201019 Vaccine BNT162b2 Under Emergency Use Listing [Internet] [cited 2023 Nov 16]. 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