{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:05:41Z","timestamp":1767164741993,"version":"build-2238731810"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This retrospective study aimed to investigate the impact of the emergence of new variants and the epidemiological scenario on hospitalization rates of unvaccinated children (0\u201312\u2009years) in Brazil. The study included 1614 children admitted to a hospital between March 2020 and December 2022 but 101 (6.3%) of them testing positive for COVID\u201019 via RT\u2010PCR. The frequency of COVID\u201019 cases increased from 7.5% in 2020 to 9.3% in 2022 with the emergence of the Omicron variant. Children over 5\u2009years old with comorbidities accounted for most cases (69% [70\/101]). Sickle cell anemia was the most frequent comorbidity (20%), and influenza\u2010like illness (36% [36\/101]) and decompensation of underlying disease (33% [33\/101]) were the main reasons for hospitalization. Coinfection was detected in 11% of cases, with respiratory syncytial virus (RSV) being the most common viral pathogen (71%). Hospital readmission occurred in 26% of cases, with a higher frequency in children over 5\u2009years old. The death rate was 1.9%, with comorbidities such as cystic fibrosis and congenital heart disease as risk factors. These findings emphasize the need to prioritize vaccination with monovalent Omicron XBB for high\u2010risk groups, including children over 5\u2009years old with comorbidities, to mitigate the impact of new variants and reduce severe disease outcomes.<\/jats:p>","DOI":"10.1111\/irv.70011","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T02:23:22Z","timestamp":1734402202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Variants, Epidemiological Trends, and Comorbidities on Hospitalization Rates of Unvaccinated Children in Brazil: A Retrospective Study (2020\u20132022)"],"prefix":"10.1111","volume":"18","author":[{"given":"Danielle Dias","family":"Conte","sequence":"first","affiliation":[{"name":"Infectious Diseases Division Universidade Federal de S\u00e3o Paulo, UNIFESP  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00ed Andr\u00e9 Silva","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division Universidade Federal de S\u00e3o Paulo, UNIFESP  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula Cunha","family":"Chaves","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division Universidade Federal de S\u00e3o Paulo, UNIFESP  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Alberto\u2010Lei","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division Universidade Federal de S\u00e3o Paulo, UNIFESP  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Helena Sita","family":"Perosa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division Universidade Federal de S\u00e3o Paulo, UNIFESP  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division Universidade Federal de S\u00e3o Paulo, UNIFESP  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Bellei","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division Universidade Federal de S\u00e3o Paulo, UNIFESP  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Minist\u00e9rio da Sa\u00fade \u201cSecretaria de Vigil\u00e2ncia em Sa\u00fade. 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