{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:44:53Z","timestamp":1775612693144,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH266"],"award-info":[{"award-number":["ZR2021MH266"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Influenza virus infection may lead to fatal complications including multi\u2010organ failure and sepsis. The influenza virus was detected in various extra\u2010pulmonary organs in autopsy studies during the 2009 pandemic. However, limited research has been conducted on the presence of viral particle or viral components in the peripheral blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>We established a mouse model for severe H1N1 influenza. The bile and blood samples were collected over time and inoculated into embryonated chicken eggs. We detected live influenza virus in bile and blood samples in early infection. Immunofluorescence showed influenza viral components in the liver tissue. No live virus was isolated in the bile in mice intragastrically administered with influenza virus, indicating that the virus was spread from the blood stream. Targeted metabolomics analysis of bile acid and liver tissues showed that a secondary bile acid (3\u2010dehydrocholic acid) was decreased after influenza H1N1 infection. Genes related with fatty acid metabolism and bile secretion pathways were down\u2010regulated in liver after influenza virus infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study indicated that influenza virus viremia is present in severe influenza, and that the liver is a target organ for influenza viral sepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70012","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T03:07:04Z","timestamp":1729825624000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Detection of H1N1 Influenza Virus in the Bile of a Severe Influenza Mouse Model"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7337-3869","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Health and Multimorbidity National Center for Respiratory Medicine  China"},{"name":"National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine Chinese Academy of Medical Sciences  China"},{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine China\u2010Japan Friendship Hospital, Capital Medical University  Beijing China"},{"name":"Department of Critical Care Medicine Yantai Affiliated Hospital of Binzhou Medical University  Yantai Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuyang","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Health and Multimorbidity National Center for Respiratory Medicine  China"},{"name":"National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine Chinese Academy of Medical Sciences  China"},{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine China\u2010Japan Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Peking University China\u2010Japan Friendship School of Clinical Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yitian","family":"Xu","sequence":"additional","affiliation":[{"name":"Peking Union Medical College and Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Lyu","sequence":"additional","affiliation":[{"name":"Peking Union Medical College and Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhi","family":"Sun","sequence":"additional","affiliation":[{"name":"Tsinghua University School of Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine China\u2010Japan Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Health and Multimorbidity National Center for Respiratory Medicine  China"},{"name":"National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine Chinese Academy of Medical Sciences  China"},{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine China\u2010Japan Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00982-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1754135"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0038-2020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03315.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23317"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix412"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.03.017"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-021-01709-7"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.11.020"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13316-w"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.2.669-676.2005"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1903207"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab382"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa709"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-021-00998-8"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1710584"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30920-X"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00805-x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39569-0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02844-23"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2192547"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115922"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00518-22"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1197847"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2015.1005474"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.134643"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO04387K"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.13"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1137369"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.70012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T01:09:54Z","timestamp":1730336994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.70012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/irv.70012"],"URL":"https:\/\/doi.org\/10.1111\/irv.70012","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.70012\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70012\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70012\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70012\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70012\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70012"}}