{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:52:52Z","timestamp":1791622372993,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme United Kingdom","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>COVID\u201019\u2010associated hospitalization rates by age and comorbid conditions can more precisely assess risk for severe illness and target prevention and treatment strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study to estimate population\u2010based COVID\u201019\u2010associated hospitalization among patients by age and selected comorbid conditions in three hospital systems in Rochester and New York City (NYC), NY. Incidence rate ratios (IRR) comparing incidence rates for patients with and without these comorbidities were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From March 2020 to December 2021, 7779 patients were hospitalized with COVID\u201019 of whom 43.8% had \u22653 comorbid conditions. Overall annual incidence ranged from 325.3 to 965.8 per 100,000 persons. Age group\u2010specific incidence was lowest in children 10\u201314\u2009years (range 4.4\u201358.9) and highest in adults \u226585\u2009years (range 2790.5\u20135889.6). Incidence rates for comorbid conditions generally increased with increasing age while IRR decreased with increasing age. Children in NYC 5\u201317\u2009years with asthma or obesity had 3.4 and 53.3 times higher hospitalization rates, respectively, than children without these conditions. Adults in all age groups with obesity, diabetes, coronary artery disease, or congestive heart failure CHF had 1.6\u20134.7 times, 1.7\u20137.2 times, 2.0\u201310.1 times, or 1.7\u201320.2 times higher hospitalization rates, respectively, than those without these conditions. Adults \u226550\u2009years with asthma had 1.5 to 1.8 times higher hospitalization rates than those without asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The burden of hospitalization with COVID\u201019 was high, particularly among adults \u226585\u2009years and adults with obesity, diabetes, CAD, or CHF. However, the impact of comorbidities was less in older adults. Population\u2010based incidence rates by age and comorbidities provide more precise estimates of the benefits of vaccines and antiviral medications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.70016","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T02:39:27Z","timestamp":1731897567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Age and Comorbid Conditions on Incidence Rates of COVID\u201019\u2010Associated Hospitalizations, 2020\u20132021"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-8451","authenticated-orcid":false,"given":"Lisa","family":"Saiman","sequence":"first","affiliation":[{"name":"Department of Pediatrics Columbia University Irving Medical Center  New York New York USA"},{"name":"Department of Infection Prevention &amp; Control New York\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward\u00a0E.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases University of Rochester  Rochester New York USA"},{"name":"Department of Medicine Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-5352","authenticated-orcid":false,"given":"Angela\u00a0R.","family":"Branche","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Columbia University Irving Medical Center  New York New York USA"},{"name":"Department of Infection Prevention &amp; Control New York\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Alba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Columbia University Irving Medical Center  New York New York USA"},{"name":"Department of Infection Prevention &amp; Control New York\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Gollerkeri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Columbia University Irving Medical Center  New York New York USA"},{"name":"Department of Infection Prevention &amp; Control New York\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia\u00a0A.","family":"Schillinger","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc  Rahway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Phillips","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc  Rahway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn","family":"Finelli","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc  Rahway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,17]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"accessed January 2024 https:\/\/covid.cdc.gov\/covid\u2010data\u2010tracker\/#trends_weeklyhospitaladmissions_select_00."},{"key":"e_1_2_9_3_1","unstructured":"accessed January 2024 https:\/\/www.cdc.gov\/coronavirus\/2019\u2010ncov\/hcp\/clinical\u2010care\/underlyingconditions.html."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab595"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/00333549211041545"},{"key":"e_1_2_9_6_1","unstructured":"access February 16 2023 https:\/\/www.health.ny.gov\/statistics\/brfss\/expanded\/."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000757"},{"key":"e_1_2_9_8_1","unstructured":"accessed 2024 https:\/\/covid.cdc.gov\/covid\u2010data\u2010tracker\/#datatracker\u2010home."},{"key":"e_1_2_9_9_1","unstructured":"COVID\u2010Net\u2013https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9169704\/."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408290102"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005382"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2912-6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab296"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2196\/34296"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040933"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2478\/jtim-2022-0020"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.46829"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2022.101704"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22732"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz570"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1419"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.6556"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13089"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.70016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T08:43:14Z","timestamp":1732610594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.70016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/irv.70016"],"URL":"https:\/\/doi.org\/10.1111\/irv.70016","archive":["Portico"],"relation":{},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70016"}}