{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:53:05Z","timestamp":1787014385988,"version":"build-2736575974"},"reference-count":138,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS\/1\/2022\/SKK12\/MUSM\/02\/1"],"award-info":[{"award-number":["FRGS\/1\/2022\/SKK12\/MUSM\/02\/1"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Enterovirus\u2010D68 (EV\u2010D68) was first identified in 1962 in pediatric patients with acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV\u2010D68 was underestimated due to limited data and serotyping methods. In 2014, the United States experienced outbreaks of acute flaccid myelitis (AFM) in children EV\u2010D68 positive. WIN\u2010like compounds (pleconaril, pocapavir, and vapendavir) bind to the virus capsid and have been tested against various enteroviruses (EVs) in clinical trials. However, these compounds encountered issues with resistance and adverse effects, which impeded their approval by the Food and Drug Administration (FDA). Presently, the medical field lacks FDA\u2010approved antiviral treatments or vaccines for EV\u2010D68. Ongoing research efforts are dedicated to identifying viable therapeutics to address EV\u2010D68 infections. This review explores the current advancements in antiviral therapies and potential therapeutics to mitigate the significant impact of EV\u2010D68 infection control.<\/jats:p>","DOI":"10.1111\/irv.70064","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T23:30:47Z","timestamp":1734651047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Emerging Therapeutics in the Fight Against EV\u2010D68: A Review of Current Strategies"],"prefix":"10.1111","volume":"18","author":[{"given":"Nida","family":"Kalam","sequence":"first","affiliation":[{"name":"Infection and Immunity Research Strength, Jeffrey Cheah School of Medicine and Health Sciences Monash University Malaysia  Bandar Sunway Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9583-307X","authenticated-orcid":false,"given":"Vinod\u00a0R.\u00a0M.\u00a0T.","family":"Balasubramaniam","sequence":"additional","affiliation":[{"name":"Infection and Immunity Research Strength, Jeffrey Cheah School of Medicine and Health Sciences Monash University Malaysia  Bandar Sunway Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a120693"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2023.105512"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06112-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006199"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11050460"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.79925-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2503.180960"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vew015"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00335-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)70093-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02370-19"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00578-19"},{"issue":"40","key":"e_1_2_9_14_1","first-page":"903","article-title":"Acute Flaccid Paralysis With Anterior Myelitis \u2010 California, June 2012\u2010June 2014","volume":"63","author":"Ayscue P.","year":"2014","journal-title":"MMWR Morbidity and Mortality Weekly Report"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30094-X"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24730"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12300"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073816680770"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.06.079"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201412-592FR"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0005-4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2208.151949"},{"issue":"10","key":"e_1_2_9_23_1","article-title":"Two Cases of Acute Severe Flaccid Myelitis Associated With Enterovirus D68 Infection in Children, Norway, Autumn 2014","volume":"20","author":"Pfeiffer H. C.","year":"2015","journal-title":"Euro Surveillance"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00029"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9865"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524498113"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.09.013"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/317145a0"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2994218"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fviro.2024.1328457"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-3900-0_36"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1261962"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-014-0087-6"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02076-07"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00801-23"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1054"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01123-12"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00876-17"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000281"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001060"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw372"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2017.05.009"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2017.12.001"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2019.09.006"},{"issue":"46","key":"e_1_2_9_45_1","article-title":"Severe Paediatric Conditions Linked With EV\u2010A71 and EV\u2010D68, France, May to October 2016","volume":"21","author":"Antona D.","year":"2016","journal-title":"Euro Surveillance"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001668"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2301.161313"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2016.21.46.30403"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2503.170897"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009637117"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.07.298"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2017.1400176"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2017.04.003"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23661"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14096"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002188"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4188"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24738"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01541"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-00415-2"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201847528"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00620-21"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05779-1"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000330"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01708-21"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.749618"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2021.105177"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2017.03.009"},{"key":"e_1_2_9_69_1","article-title":"Strain Dependent Structural Effects and in Vivo Efficacy of Enterovirus\u2010D68 Inhibitors","volume":"2021","author":"Lane T.","year":"2021","journal-title":"bioRxiv."},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.112007"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00872"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01311"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00156-23"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00383"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01029-21"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01375-15"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00204-20"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00115"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-021-00410-x"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix468"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aba4902"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6214"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02407"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00404"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00766-15"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006670"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.9.2109"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00277-3"},{"issue":"3","key":"e_1_2_9_89_1","first-page":"335","article-title":"Antiviral Activity of Pocapavir in a Randomized, Blinded, Placebo\u2010Controlled Human Oral Poliovirus Vaccine Challenge Model","volume":"215","author":"Collett M. S.","year":"2017","journal-title":"Journal of Infectious Diseases"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.6.1220"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00671-09"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00284"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu105"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.02.011"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab113"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02084-12"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00179"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000904"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.04.003"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i2.201"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.10.2444"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02221-18"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml2002955"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12101178"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2003.11.001"},{"issue":"5","key":"e_1_2_9_106_1","first-page":"303","article-title":"In Vitro Inhibitory Effects of Dual Combinations of Picornavirus Replication Inhibitors","volume":"43","author":"Nikolaeva L.","year":"1999","journal-title":"Acta Virologica"},{"issue":"2","key":"e_1_2_9_107_1","first-page":"91","article-title":"Antiviral Combination Approach as a Perspective to Combat Enterovirus Infections","volume":"36","author":"Galabov A. S.","year":"2015","journal-title":"Pril (Makedon Akad Nauk Umet Odd Med Nauki)."},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01073-16"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2024.105842"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.11.012"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166336"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101053"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00833-22"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-2867(97)80031-X"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.06.086"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289303200912"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.5.1201"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2016-0049"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.614743"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800655"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0275-7"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00737.x"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00918-08"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01627-15"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.806084"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir174"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02395-15"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.11.013"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00342"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132998"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04214-8"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.04.006"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3369"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.732891"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.10.006"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08485-x"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.03.004"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/846740"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-014-1860-0"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.70064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T06:57:56Z","timestamp":1740898676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.70064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":138,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/irv.70064"],"URL":"https:\/\/doi.org\/10.1111\/irv.70064","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.70064\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70064\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70064\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70064\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70064\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70064\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70064\/v2\/review2","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70064"}}