{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:40:05Z","timestamp":1788748805070,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T00:00:00Z","timestamp":1738454400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate cost estimates of respiratory syncytial virus (RSV) infections in primary care are limited, despite the majority of cases being managed in this setting. This study aims to estimate healthcare costs for children with RSV in primary care and the related costs of parental work absence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children &lt;\u20095\u2009years of age with symptoms of acute respiratory infections were recruited via primary care paediatricians in two Italian regions for a prospective cohort study on the RSV burden in primary care, during the 2019\/2020 winter. Healthcare utilization, medication use and parental work absence were assessed during a 14\u2010day follow\u2010up period. Average costs were estimated per RSV episode for the overall study population, as well as per age group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred ninety three children were recruited, of which 119 tested RSV positive (41%) and 109 were included. In total, 89% of RSV\u2010positive children (97\/109) had \u2265\u20091 repeat paediatrician visit(s), and 10% (11\/109) visited the ED. The mean number of repeat visits was 3.8 (SD: 4.0) and the mean duration of work absence 4.0\u2009days (SD: 5.0). Average costs per RSV episode were \u20ac730 (95% CI: \u20ac691\u2013\u20ac771), with direct medical costs accounting for 25% (\u20ac183 [95% CI: \u20ac174\u2013\u20ac191]) and indirect costs related to work absence for 75% (\u20ac547 [95% CI: \u20ac509\u2013\u20ac587]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Costs associated with RSV infections in young children in primary care are considerable due to a substantial number of paediatrician visits and high rates of parental work absence. These costs are important to include in decision\u2010making regarding the implementation of new RSV immunization strategies in national immunization programmes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70074","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T02:43:47Z","timestamp":1738550627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Economic Impact of Respiratory Syncytial Virus Infections in Children Under 5\u2009Years of Age Attending Primary Care in Italy: A Prospective Cohort Study in Two Regions"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6004-4117","authenticated-orcid":false,"given":"Val\u00e9rie\u00a0D.\u00a0V.","family":"Sankatsing","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases in Primary Care Nivel, Netherlands Institute for Health Services Research  Utrecht 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