{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:43:33Z","timestamp":1792597413192,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["PE00000007"],"award-info":[{"award-number":["PE00000007"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Respiratory viruses are major contributors to morbidity and mortality worldwide, with their circulation influenced by seasonal patterns and pandemic\u2010related interventions. This study analyzed detection trends of non\u2010SARS\u2010CoV\u20102 respiratory viruses in a large Italian hospital over a 7\u2010year period, focusing on variations across COVID\u201019\u2013related periods and patient age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed multiplex PCR\u2010based laboratory results of 8836 nasopharyngeal samples collected between September 2016 and August 2023. Viral detection rates were stratified by season, COVID\u201019\u2013related periods (pre\u2010pandemic, pandemic, post\u2010pandemic), and age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 8836 nasopharyngeal samples analyzed, 2795 (31.6%) tested positive for at least one respiratory virus. Rhinovirus\/enterovirus (RV\/EV) was the most frequently detected virus (37.6%), followed by influenza A virus (IAV, 17.9%) and respiratory syncytial virus (RSV, 17.2%). The 2020\u20132021 season had the lowest positivity rate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with marked declines in IAV and RSV detections, likely because of COVID\u201019 mitigation measures. Conversely, detections of RV\/EV and human coronaviruses increased. Postpandemic data suggested a return to prepandemic patterns, though overall positivity rates remained altered. Age\u2010stratified analysis revealed RSV predominance in infants (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), emphasizing its clinical relevance in pediatric populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings highlight the dynamic nature of respiratory virus epidemiology and the persistent impact of the COVID\u201019 pandemic on viral circulation. Continuous surveillance and adaptive public health strategies are essential for managing future outbreaks and mitigating the burden of respiratory viral infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70079","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T19:08:31Z","timestamp":1740078511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Detection of Respiratory Viruses Other Than SARS\u2010CoV\u20102 in a Large Hospital Laboratory in Rome, Italy, During the Seasons 2016\u20132017 to 2022\u20132023"],"prefix":"10.1111","volume":"19","author":[{"given":"Flora\u00a0Marzia","family":"Liotti","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze di Laboratorio ed Ematologiche Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze di Laboratorio ed Ematologiche Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"D'Onghia","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze di Laboratorio ed Ematologiche Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-7059","authenticated-orcid":false,"given":"Maurizio","family":"Sanguinetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze di Laboratorio ed Ematologiche Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Santangelo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze di Laboratorio ed Ematologiche Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunella","family":"Posteraro","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00103\u201020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025120\u20106"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.05.042"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(18)30310\u20104"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab942"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15040934"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.909"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13199"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010022\u201014088\u20107"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010virology\u2010012420\u2010022445"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202115352"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010023\u201000919\u2010w"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1200617"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2802.211727"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18189525"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:46:45Z","timestamp":1741693605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/irv.70079"],"URL":"https:\/\/doi.org\/10.1111\/irv.70079","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.70079\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70079\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70079\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70079\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70079"}}