{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:28:26Z","timestamp":1777948106693,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to estimate the incidence of respiratory syncytial virus (RSV) infections in US inpatient and outpatient settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We established national cohorts of privately insured children &lt;\u20095\u2009years (2011\u20132019) to estimate annual and seasonal incidences of lower respiratory tract infection (LRTI), RSV\u2010LRTI, and RSV acute respiratory infection (RSV\u2010ARI), stratified by age and high\u2010risk conditions per American Academy of Pediatrics definitions. Sensitivity analyses varied episode definitions and assessed the impact of immunoprophylaxis and RSV under\u2010ascertainment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 6,767,107 children, annual RSV\u2010LRTI rates dropped with increasing age in both inpatient (7.9 for age &lt;\u20091\u2009year to 0.2 for age 4 per 1000 person\u2010years) and outpatient settings (48.3 to 1.6). Most RSV\u2010ARI (~80%\u201390%) was RSV\u2010LRTI. RSV\u2010LRTI accounted for &gt;\u2009half of LRTI hospitalizations among infants (7.9 RSV\u2010LRTI versus 14.7 LRTI) and for ~20% outpatient LRTI (48.3 versus 250.3), but this contribution declined with older age. Outpatient RSV\u2010LRTI was &gt;\u20095 times inpatient rates.<\/jats:p>\n                    <jats:p>Inpatient RSV\u2010LRTI rates dropped consistently with increasing gestational age (GA) (35.6 for GA\u2009&lt;\u200929\u2009weeks versus 7.6 for term infants), while outpatient rates were similar across GA groups (54.0 versus 51.6). Infants with Down syndrome had the highest RSV\u2010LRTI rates, and any high\u2010risk group had rates &gt;2 times higher than healthy term infants. Across all strata, seasonal rates were &gt;\u20092 annual rates. Modeling suggested that claims data captured 42% of all RSV episodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides national, population\u2010based estimates of medically attended RSV infections across age groups and high\u2010risk strata. Results allow granular assessments of disease burden to guide recommendations for new RSV prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70094","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T17:29:05Z","timestamp":1743787745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Respiratory Syncytial Virus Incidence in Young Children in the United States: Impact of Methodologies and Patient Characteristics"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6383-2603","authenticated-orcid":false,"given":"Sabina\u00a0O.","family":"Nduaguba","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy, College of Pharmacy University of Florida  Gainesville Florida USA"},{"name":"Department of Pharmaceutical Systems and Policy School of Pharmacy  Morgantown West Virginia USA"},{"name":"West Virginia University Cancer Institute  Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-1576","authenticated-orcid":false,"given":"Phuong\u00a0T.","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy, College of Pharmacy University of Florida  Gainesville Florida USA"},{"name":"Faculty of Pharmacy HUTECH University  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5213-9301","authenticated-orcid":false,"given":"Renata","family":"Shih","sequence":"additional","affiliation":[{"name":"Congenital Heart Center University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyn","family":"Finelli","sequence":"additional","affiliation":[{"name":"Center for Observational and Real\u2010World Evidence Merck &amp; Co., Inc  Rahway New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8810-7579","authenticated-orcid":false,"given":"Yoonyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Observational and Real\u2010World Evidence Merck &amp; Co., Inc  Rahway New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanning","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Drug Evaluation and Safety University of Florida  Gainesville Florida USA"},{"name":"Department of Health Outcomes and Biomedical Informatics, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6518-5961","authenticated-orcid":false,"given":"Almut\u00a0G.","family":"Winterstein","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Outcomes and Policy, College of Pharmacy University of Florida  Gainesville Florida USA"},{"name":"Center for Drug Evaluation and Safety University of Florida  Gainesville Florida USA"},{"name":"Department of Epidemiology, College of Medicine and College of Public Health and Health Professions University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(22)00478\u20130"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.3.419"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"55","article-title":"Respiratory Syncytial Virus and Premature Infants Born at 32 Weeks' Gestation or Earlier: Hospitalization and Economic Implications of Prophylaxis","volume":"154","author":"Stevens T. 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