{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T20:54:11Z","timestamp":1781384051368,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>RSV incidence in adults is frequently underestimated due to non\u2010specific symptomatology, limited standard\u2010of\u2010care testing, and lower test sensitivity compared to infants. We conducted a retrospective observational study to estimate RSV\u2010attributable incidence of specific types of cardiorespiratory hospitalizations among adults in Germany between 2015 and 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Information on hospitalizations and the number of people at risk of hospitalization (denominator) was gathered from a Statutory Health Insurance database. A quasi\u2010Poisson regression model accounting for periodic and aperiodic time trends and virus activity was fitted to estimate the RSV\u2010attributable incidence rate (IR) of four specific cardiovascular hospitalizations (arrhythmia, ischemic heart diseases, chronic heart failure exacerbations, and cerebrovascular diseases) and four specific respiratory hospitalizations (influenza\/pneumonia, bronchitis\/bronchiolitis, chronic lower respiratory tract diseases, and upper respiratory tract diseases).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The estimated RSV\u2010attributable IRs of hospitalizations generally increased with age. Among estimated cardiovascular hospitalizations in adults aged \u2265\u200960\u2009years, arrhythmia and ischemic heart diseases accounted for the highest incidence of RSV\u2010attributable events, followed by chronic heart failure exacerbation, with annual IR ranges of 157\u2013260, 133\u2013214, and 105\u2013169 per 100,000 person\u2010years, respectively. The most frequent RSV\u2010attributable respiratory hospitalizations in adults aged \u2265\u200960\u2009years were estimated for chronic lower respiratory tract diseases and bronchitis\/bronchiolitis, with annual IR ranges of 103\u2013168 and 77\u2013122 per 100,000 person\u2010years, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RSV causes a considerable burden of respiratory and cardiovascular hospitalizations in adults in Germany, similar to other respiratory viruses (e.g., influenza and SARS\u2010CoV\u20102). This highlights the need to implement effective prevention strategies, especially for older adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.70097","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T07:54:55Z","timestamp":1745826895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Estimated Incidence Rate of Specific Types of Cardiovascular and Respiratory Hospitalizations Attributable to Respiratory Syncytial Virus Among Adults in Germany Between 2015 and 2019"],"prefix":"10.1111","volume":"19","author":[{"given":"Caihua","family":"Liang","sequence":"first","affiliation":[{"name":"Pfizer Inc  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0148-7183","authenticated-orcid":false,"given":"Aleksandra","family":"Polkowska\u2010Kramek","sequence":"additional","affiliation":[{"name":"P95 Epidemiology &amp; Pharmacovigilance  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Lade","sequence":"additional","affiliation":[{"name":"Pfizer Pharma GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea\u00a0J.","family":"Bayer","sequence":"additional","affiliation":[{"name":"Pfizer Pharma GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Bruyndonckx","sequence":"additional","affiliation":[{"name":"P95 Epidemiology &amp; 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