{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:06:40Z","timestamp":1790694400856,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00377"],"award-info":[{"award-number":["PI21\/00377"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21CIII\/00019"],"award-info":[{"award-number":["PI21CIII\/00019"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nirsevimab, a monoclonal antibody providing passive immunity against RSV infections in infants, was introduced in Spain in October 2023 for children under 6\u2009months and those born during the epidemic season. This study aimed to compare the clinical and virological characteristics of respiratory infections in hospitalized infants before and after nirsevimab introduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We carried out a prospective study across two hospitals in Madrid during the 2022\u20132023 and 2023\u20132024 epidemic seasons. The study included infants under 12\u2009months of age that were hospitalized with lower respiratory tract infections (LRTIs). Clinical, epidemiological, and virological data were analyzed and compared between the periods before and after the introduction of nirsevimab, as well as according to whether the infants had received this preventive treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 669 infants were included: 480 from October 2022 to March 2023 (S1) and 189 from October 2023 to March 2024 (S2). Respiratory infection\u2013related admissions decreased by 62.5% in S2, with a 74.5% reduction in ICU admissions. RSV\u2010related admissions decreased by 78%, HMPV by 36.6%, and adenovirus by 69.5%. Infants in S2 were older (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and had shorter hospital stays (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) than in S1. Of 63 (33%) infants in S2 who received nirsevimab, 11 (17%) were diagnosed with RSV. High\u2010flow oxygen use was less frequent among RSV patients treated with nirsevimab (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nirsevimab introduction was significantly associated with reduced hospitalizations and severity of RSV and other respiratory infections. Its use was associated with fewer admissions and reduced need for intensive care, especially in RSV\u2010infected infants but also in HMPV and adenovirus\u2010infected infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70105","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:56:44Z","timestamp":1745974604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of Nirsevimab on RSV and Non\u2010RSV Severe Respiratory Infections in Hospitalized Infants"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4906-4227","authenticated-orcid":false,"given":"Mar\u00eda\u00a0Luz","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Pediatrics Department Severo Ochoa University Hospital  Legan\u00e9s Spain"},{"name":"Puerta de Hierro Institute for Health Research (IDIPHISA)  Majadahonda Spain"},{"name":"Center for Biomedical Research in the Infectious Diseases Network (CIBERINFEC) Instituto de Salud Carlos III (ISCIII)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Alonso\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pediatrics Department Severo Ochoa University Hospital  Legan\u00e9s Spain"},{"name":"Puerta de Hierro Institute for Health Research (IDIPHISA)  Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Alcolea","sequence":"additional","affiliation":[{"name":"Pediatrics Department Severo Ochoa University Hospital  Legan\u00e9s Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Arroyas","sequence":"additional","affiliation":[{"name":"Pediatrics Department Severo Ochoa University Hospital  Legan\u00e9s Spain"},{"name":"Puerta de Hierro Institute for Health Research (IDIPHISA)  Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Pozo","sequence":"additional","affiliation":[{"name":"Reference and Research Laboratory for Respiratory Virus National Centre for Microbiology, Instituto de Salud Carlos III (ISCIII)  Majadahonda Madrid Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) Instituto de Salud Carlos III (ISCIII)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Casas","sequence":"additional","affiliation":[{"name":"Reference and Research Laboratory for Respiratory Virus National Centre for Microbiology, Instituto de Salud Carlos III (ISCIII)  Majadahonda Madrid Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) Instituto de Salud Carlos III (ISCIII)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Iglesias\u2010Caballero","sequence":"additional","affiliation":[{"name":"Reference and Research Laboratory for Respiratory Virus National Centre for Microbiology, Instituto de Salud Carlos III (ISCIII)  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"S\u00e1nchez\u2010Le\u00f3n","sequence":"additional","affiliation":[{"name":"Pediatric Infectious and Tropical Diseases Department La Paz University Hospital. La Paz Institute for Health Research (IdiPAZ), P\u00b0 de la Castellana  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jara","family":"Hurtado\u2010Gallego","sequence":"additional","affiliation":[{"name":"Pediatric Infectious and Tropical Diseases Department La Paz University Hospital. La Paz Institute for Health Research (IdiPAZ), P\u00b0 de la Castellana  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-3423","authenticated-orcid":false,"given":"Cristina","family":"Calvo","sequence":"additional","affiliation":[{"name":"Center for Biomedical Research in the Infectious Diseases Network (CIBERINFEC) Instituto de Salud Carlos III (ISCIII)  Madrid Spain"},{"name":"Pediatric Infectious and Tropical Diseases Department La Paz University Hospital. La Paz Institute for Health Research (IdiPAZ), P\u00b0 de la Castellana  Madrid Spain"},{"name":"European Society For Paediatric Infectious Diseases (ESPID)  Seafield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08358-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00478-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00414-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1665"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7234a4"},{"key":"e_1_2_8_7_1","unstructured":"\u201cDocumento t\u00e9cnico de Inmunizaci\u00f3n frente al Virus Respiratorio Sincitial (VRS) en lactantes en la Comunidad de Madrid en la temporada 2024\u20102025 \u201d Direcci\u00f3n General de Salud P\u00fablica. 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