{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:02:16Z","timestamp":1790240536950,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although reports have documented prolonged SARS\u2010CoV\u20102 RNA detection in immunocompromised patients, few studies have systematically analyzed data on duration of SARS\u2010CoV\u20102 in respiratory specimens of immunocompromised patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was undertaken to describe SARS\u2010CoV\u20102 RNA and infectious virus detection in immunocompromised patients from published data between January 1, 2020 and July 1, 2022. Patients were included if there was \u2265\u20091 positive SARS\u2010CoV\u20102 RNA result in respiratory specimens collected &gt; 20\u2009days since symptom onset or first positive SARS\u2010CoV\u20102 RT\u2010PCR result.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 183 patients, 175 were symptomatic with 83 (47.4%) that experienced intermittent relapsing symptoms, while pneumonia was reported in 122 (66.7%). Immunocompromising conditions represented were hematologic malignancy treatment (89, 48.6%), solid organ transplant (47, 25.7%), autoimmune disease treatment (14, 7.7%), solid tumor treatment (3, 1.6%), HIV infection (15, 8.2%), and primary immunodeficiency (15, 8.2%). Median duration from the first to the last positive SARS\u2010CoV\u20102 RT\u2010PCR result was 56\u2009days in upper respiratory and 60\u2009days in lower respiratory tract specimens. Significant differences in median duration of SARS\u2010CoV\u20102 RNA detection were observed between patients with and without pneumonia and for patients with hematologic malignancies compared to solid organ transplant patients. Among patients with viral culture performed, median duration of replication\u2010competent SARS\u2010CoV\u20102 was 60.5\u2009days from symptom onset (maximum 238\u2009days) and 59\u2009days from first RT\u2010PCR positive result (maximum 268\u2009days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Immunocompromised persons can have replication\u2010competent SARS\u2010CoV\u20102 in respiratory tissues for months, including while asymptomatic. Serial SARS\u2010CoV\u20102 testing can inform the duration of isolation for immunocompromised patients with SARS\u2010CoV\u20102 infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70121","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T23:58:07Z","timestamp":1747785487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Systematic Review of Prolonged SARS\u2010CoV\u20102 Shedding in Immunocompromised Persons"],"prefix":"10.1111","volume":"19","author":[{"given":"Rebecca\u00a0C.","family":"Christofferson","sequence":"first","affiliation":[{"name":"Louisiana State University School of Veterinary Medicine  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer\u00a0E.","family":"Giovanni","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia 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