{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:41:17Z","timestamp":1793810477830,"version":"4.6.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) and influenza virus are important respiratory viruses. Although RSV vaccines have been developed and recommended for patients aged \u2265 60, there is limited data on the clinical impact among the non\u2010elderly population. It is also important to know the patient subgroups that are at risk of complications from RSV infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a territory\u2010wide retrospective study on adults hospitalized for RSV or influenza virus infection between 1\/1\/2016 and 6\/30\/2023 in Hong Kong. The in\u2010patient mortality, severe respiratory failure (SRF), secondary bacterial pneumonia, and acute kidney injury (AKI) were compared. Subgroup analyses were performed in different age groups. The risk factors for mortality and serious respiratory outcomes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 41,206 and 3565 patients were hospitalized for influenza and RSV infections. Patients with RSV infection showed a significantly higher risk of in\u2010patient mortality, SRF, secondary bacterial pneumonia, and AKI compared with those with influenza (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, for all), and the results were consistent for patients aged \u2265 60, &lt; 60, and 50\u201359. End\u2010stage kidney disease requiring real replacement therapy was an independent risk factor for in\u2010patient mortality and serious respiratory outcomes in RSV infection across different age groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adults hospitalized for RSV infection were associated with a significantly increased risk of in\u2010patient mortality and adverse respiratory and kidney outcomes than those with influenza. The findings are consistent across various age groups, and the results call for an update on RSV vaccination recommendations in adults, especially for vulnerable subgroups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70130","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T05:04:44Z","timestamp":1750395884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["In\u2010Hospital Mortality and Severe Respiratory and Renal Outcomes\u2014A Territory\u2010Wide Comparison Between RSV and Influenza"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5611-1637","authenticated-orcid":false,"given":"Wang\u00a0Chun","family":"Kwok","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine The University of Hong Kong, Queen Mary Hospital  Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac\u00a0Sze\u00a0Him","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Statistics The Chinese University of Hong Kong  Shatin New Territories Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James\u00a0Chung\u00a0Man","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine The University of Hong Kong, Queen Mary Hospital  Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u00a0Ki","family":"Tsui","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine The University of Hong Kong, Queen Mary Hospital  Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0Chi\u00a0Leung","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine The University of Hong Kong, Queen Mary Hospital  Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u00a0Sau\u00a0Man","family":"Ip","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine The University of Hong Kong, Queen Mary Hospital  Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin\u00a0Kai\u00a0Wang","family":"To","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine The University of Hong Kong  Pokfulam Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desmond\u00a0Yat\u00a0Hin","family":"Yap","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine The University of Hong Kong, Queen Mary Hospital  Pokfulam Hong Kong 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