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This study provides an approximate estimate of the global disease burden from the pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort study followed the Qatari population from the onset of the pandemic to March 18, 2024, to estimate the age\u2010specific incidence rates of severe, critical, and fatal COVID\u201019, classified according to World Health Organization criteria. A mathematical model then utilized these rates to generate regional and global estimates of COVID\u201019 severity and fatality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence rate of any severe, critical, or fatal COVID\u201019 throughout the pandemic was 1.13 (95% CI: 1.07\u20131.19) per 1000 person\u2010years, while that of fatal COVID\u201019 alone was 0.11 (95% CI: 0.09\u20130.13) per 1000 person\u2010years. Globally, the number of severe, critical, or fatal COVID\u201019 cases was estimated at 61.9 million (95% UI: 55.0\u201369.9 million), while the number of fatal COVID\u201019 cases alone was estimated at 11.3 million (95% UI: 7.8\u201317.4 million). Both estimates showed large regional variations. Most severe, critical, and fatal COVID\u201019 cases occurred during the pre\u2010Omicron phase of the pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The COVID\u201019 pandemic had a profound global impact on morbidity and mortality, emphasizing the critical need for preparedness for future pandemics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70154","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:11:05Z","timestamp":1764645065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Global Estimates of COVID\u201019 Morbidity and Mortality: A Cohort Study and Mathematical Model 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