{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:47:04Z","timestamp":1772160424928,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study compared the diagnostic accuracy of seven different commercial serological assays for COVID\u201019, using RT\u2010PCR as the gold standard, through meta\u2010analysis and indirect comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010seven studies, published from November 2019 to June 2024, were included. The diagnostic performance of IgA, IgG, and total antibody assays for SARS\u2010CoV\u20102 was assessed. The netmeta, rjags, and gemtc packages in R software were used for adjusted indirect comparison to calculate the relative diagnostic odds ratio (RDOR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The pooled diagnostic odds ratio (DOR) for Abbott SARS\u2010CoV\u20102 IgG was 542.81, for Elecsys Anti\u2010SARS\u2010CoV\u20102 N was 1022.34, for Elecsys Anti\u2010SARS\u2010CoV\u20102 total was 1701.56, for Euroimmun Anti\u2010SARS\u2010CoV\u20102 IgA was 45.91, for Euroimmun Anti\u2010SARS\u2010CoV\u20102 S1\u2010IgG was 190.45, for Euroimmun Anti\u2010SARS\u2010CoV\u20102 N\u2010IgG was 82.63, and for LIAISON SARS\u2010CoV\u20102 S1\/S2 IgG was 178.73. The pooled DOR for IgG, IgA, and total antibody assays was 241.43, 45.91, and 1124.48. The pooled DOR for the antinucleocapsid antigen (anti\u2010N) was 604.29; for the antidomain of viral spike protein (anti\u2010S1) and the antirecombinant S1 and S2 (anti\u2010S1\/S2) antigens, the pooled DORs were 119.88 and 178.73. ECLIA and CMIA methods had superior diagnostic performance compared with CLIA and ELISA, with no significant difference between ECLIA and CMIA. Total antibody assays showed the highest accuracy, followed by IgG, with IgA performing least effectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elecsys Anti\u2010SARS\u2010CoV\u20102 total and N assays had the best overall diagnostic test accuracy. The diagnostic efficacy of the anti\u2010N total, IgG antibodies was statistically significantly higher than that of anti\u2010S IgG and IgA antibodies for COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70155","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T10:02:16Z","timestamp":1757412136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Indirect Comparison of Diagnostic Accuracy for Seven Different SARS\u2010CoV\u20102 Serological Assays: A Meta\u2010Analysis and Adjusted Indirect Comparison of Diagnostic Test Accuracy"],"prefix":"10.1111","volume":"19","author":[{"given":"Minjie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Xian Yang Central Hospital  Xianyang 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