{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:19:09Z","timestamp":1792811949540,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human metapneumovirus (hMPV) has been increasingly recognized as a major contributor to respiratory infections in all age groups. Owing to its recent discovery, available data on the burden of hMPV in adults are still scant and heterogeneous. Here, we aimed to explore the epidemiology, symptomatic profile, and mortality related to hMPV among Italian adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed an integrated analysis of several community\u2010based and hospital\u2010based studies conducted in Genoa (Italy) between 2014 and 2025. Adults aged \u2265\u200918\u2009years prescribed with \u2265\u20091 molecular test for hMPV were eligible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 21,580 and 2671 adults included in the hospital\u2010based and community\u2010based studies, 376 and 117, respectively, tested positive for hMPV. Seasonal (November to April) hMPV detection rate was 4.4% (95% CI: 3.6%\u20135.2%) in the community\u2010based and 2.4% (95% CI: 2.1%\u20132.6%) in the hospital\u2010based studies. Most detections occurred during the spring months. Each 1\u2010year increase in age was associated with a 1.1% increase in the odds of hMPV positivity (adjusted odds ratio [aOR] 1.011; 95% CI: 1.005\u20131.016). Clinical presentation of hMPV resembled that of the phylogenetically related respiratory syncytial virus. Among hMPV\u2010positive inpatients, 7.3% (95% CI: 4.3%\u201311.5%) died during their hospital encounter. In\u2010hospital mortality was associated with residency in long\u2010term care facilities (aOR 8.73; 95% CI: 2.63\u201329.15) and cancer (aOR 4.51; 95% CI: 1.50\u201314.35).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>hMPV is a common virological finding in outpatient and inpatient adults and is responsible for a measurable burden, especially among the most frail older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70175","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T02:06:00Z","timestamp":1761012360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiology and Burden of Human Metapneumovirus Among Italian Adults in Outpatient and Inpatient Settings, 2014\u20132025"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9608-8892","authenticated-orcid":false,"given":"Alexander","family":"Domnich","sequence":"first","affiliation":[{"name":"Hygiene Unit San Martino Polyclinic Hospital \u2013 IRCCS for Oncology and Neurosciences  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-0551","authenticated-orcid":false,"given":"Donatella","family":"Panatto","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL) University of Genoa  Genoa Italy"},{"name":"Interuniversity Research Centre on Influenza and Other Transmissible Infections (CIRI\u2010IT)  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Paolozzi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL) University of Genoa  Genoa 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